Ion Permeation, Voltage Gating and Pharmacological Modulation in K2P TREK Channels Studied by Atomistic Molecular Dynamics Simulations

被引：0
|
作者：
Sun, Han [1 ,2 ]
Turkaydin, Berke [1 ,2 ]
Aldakul, Yessenbek [1 ,2 ]
机构：
[1] Leibniz Forschungsinst Mol Pharmakol, Berlin, Germany
[2] Tech Univ Berlin, Berlin, Germany
来源：
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS | 2023年 / 52卷 / SUPPL 1期
关键词：
D O I：
暂无
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
P-483
引用
收藏
页码：S160 / S160
页数：1
相关论文
共 50 条
  • [31] Characterisation of the Versatile Gating Behaviour in Talk-2 K2P Channels
    Riel, Elena B.
    Juers, Bjoern
    Langer, Jan
    Musinszki, Marianne
    Cordeiro, Soenke
    Rinne, Susanne
    Decher, Niels
    Schewe, Marcus
    Baukrowitz, Thomas
    BIOPHYSICAL JOURNAL, 2020, 118 (03) : 269A - 269A
  • [32] Mechanistic insights into volatile anesthetic modulation of K2P channels
    Wague, Aboubacar
    Joseph, Thomas T.
    Woll, Kellie A.
    Bu, Weiming
    Vaidya, Kiran A.
    Bhanu, Natarajan, V
    Garcia, Benjamin A.
    Nimigean, Crina M.
    Eckenhoff, Roderic G.
    Riegelhaupt, Paul M.
    ELIFE, 2020, 9 : 1 - 23
  • [33] Prognostic significance of the TREK-1 K2P potassium channels in prostate cancer
    Zhang, Gui-Ming
    Wan, Fang-Ning
    Qin, Xiao-Jian
    Cao, Da-Long
    Zhang, Hai-Liang
    Zhu, Yao
    Dai, Bo
    Shi, Guo-Hai
    Ye, Ding-Wei
    ONCOTARGET, 2015, 6 (21) : 18460 - 18468
  • [34] Molecular mechanisms of activation in K2P potassium channels
    Baukrowitz, T.
    ACTA PHYSIOLOGICA, 2019, 227
  • [35] 'C-type' closed state and gating mechanisms of K2P channels revealed by conformational changes of the TREK-1 channel
    Zhang, Qiansen
    Fu, Jie
    Zhang, Shaoying
    Guo, Peipei
    Liu, Shijie
    Shen, Juwen
    Guo, Jiangtao
    Yang, Huaiyu
    JOURNAL OF MOLECULAR CELL BIOLOGY, 2022, 14 (01)
  • [36] Mechanistic Insights into Volatile Anesthetic Modulation of K2P Channels
    Riegelhaupt, Paul M.
    BIOPHYSICAL JOURNAL, 2021, 120 (03) : 248A - 248A
  • [37] Understanding the Dynamics of K2P Channels in Complex Lipid Bilayers
    Aryal, Prafulla
    Tucker, Stephen J.
    Sansom, Mark S. P.
    BIOPHYSICAL JOURNAL, 2015, 108 (02) : 436A - 437A
  • [38] Side-fenestrations of K2P channels provide the molecular basis for voltage dependent block of leak channels
    Tins, A.
    Rinne, S.
    Salekh, D.
    Kiper, A.
    Netter, M.
    Streit, A.
    Stansfeld, P.
    Gonzalez, W.
    Decher, N.
    ACTA PHYSIOLOGICA, 2015, 213 : 134 - 135
  • [39] Gating Mechanism of the Voltage-Gated Proton Channel Studied by Molecular Dynamics Simulations
    Thi Tuong Vy Phan
    Yi, Myunggi
    MOLECULES, 2022, 27 (07):
  • [40] Polymodal Gating of the TREK-2 K2P Potassium Channel Involves Structurally Distinct Open States
    McClenaghan, Conor
    Schewe, Marcus
    Baukrowitz, Thomas
    Tucker, Stephen J.
    BIOPHYSICAL JOURNAL, 2016, 110 (03) : 607A - 607A
12345