Reaction of Highly Volatile Organic Compounds with Organolithium Species in Flow Microreactor

被引：2

作者：

Muta, Kensuke ^{[1
]}

Okamoto, Kazuhiro ^{[2
]}

Nagaki, Aiichiro ^{[2
]}

机构：

[1] Cent Glass Co Ltd, Fundamental Chem Res Ctr, 17-5 Nakadai 2 Chome, Kawagoe, Saitama 3501159, Japan

[2] Hokkaido Univ, Grad Sch Sci, Dept Chem, Kita 10 Jo, Nishi 8 Chome, Kita Ku, Sapporo 0600810, Japan

来源：

SYNLETT | 2024年 / 35卷 / 11期

基金：

日本学术振兴会;

关键词：

volatile organic compounds; organolithium species; flow chemistry; reactive intermediates; device control; CHEMISTRY; GENERATION; REACTORS;

D O I：

10.1055/a-2170-2976

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Highly volatile organic compounds (VOCs) with boiling points (bp) around or below room temperature are generally difficult to manipulate precisely in liquid-phase organic reactions although they offer significant atom-economic advantages. We have developed a novel approach using a jacketed syringe pump to enable the formylation of organolithium species in a continuous-flow system under ambient pressure. Methyl formate (bp 32 degrees C) worked as a formylating agent and was successfully delivered to the continuous operation for over 30 minutes in our microflow system. This methodology was successfully expanded to the application of acetaldehyde (bp 21 degrees C) and heptafluoropropyl bromide (bp 12 degrees C).

引用

页码：1259 / 1264

页数：6

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