3D Printing Silk Fibroin/Hydroxyapatite/Sodium Alginate Composite Scaffolds for Bone Tissue Engineering

被引：2
|
作者：
Xu, Zhenyu [1 ]
Li, Ke [1 ]
Zhou, Kui [1 ,2 ]
Li, Shuiyuan [1 ]
Chen, Hongwei [1 ]
Zeng, Jiaqi [1 ]
Hu, Rugang [1 ]
机构：
[1] Nanchang Univ, Sch Adv Mfg, Nanchang 330031, Peoples R China
[2] Nanchang Univ, Nanchang Municipal Key Lab 3D Bioprinting Technol, Nanchang 330031, Peoples R China
来源：
FIBERS AND POLYMERS | 2023年 / 24卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Bone tissue engineering; Hydroxyapatite; Silk fibroin; Sodium alginate; Composite scaffolds; BMP-INDUCED OSTEOGENESIS; IN-VITRO; FIBROIN; HYDROXYAPATITE; EXPRESSION; GEOMETRY; DEGRADATION; COLLAGEN;
D O I：
10.1007/s12221-023-00090-2
中图分类号：
TB3 [工程材料学]; TS1 [纺织工业、染整工业];
学科分类号：
0805 ; 080502 ; 0821 ;
摘要：
Silk Fibroin (SF) is a protein polymer with great biocompatibility, which can promote cell proliferation and differentiation, and enhance bone repair. In this paper, the effects of distinctive concentrations of SF solutions on the physicochemical and biological properties of the SF-HA-SA scaffolds were investigated. The SF-HA-SA porous scaffolds were prepared utilizing the pneumatic extrusion 3D printing technique, composed of hydroxyapatite (HA) and different concentrations of SF solution, and sodium alginate (SA) as a binder. The results shown the SF-HA-SA scaffolds can promote cell proliferation with the increase of SF concentration in scaffolds, and the strength meets the necessities of trabecular bone defects of bone and cartilage repair. It provides an important reference for the application of SF in bone tissue engineering.
引用
收藏
页码：275 / 283
页数：9
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