BIRC5 Gene Polymorphisms Are Associated with a Higher Stage of Local and Regional Disease in Oral and Oropharyngeal Squamous Cell Carcinomas

被引：2
|
作者：
Mumlek, Ivan [1 ,2 ]
Ozretic, Petar [3 ]
Sabol, Maja [3 ]
Leovic, Matko [4 ]
Glavas-Obrovac, Ljubica [2 ]
Leovic, Dinko [5 ]
Musani, Vesna [3 ]
机构：
[1] Univ Hosp Ctr Osijek, Dept Maxillofacial & Oral Surg, Josipa Huttlera 4, Osijek 31000, Croatia
[2] Josip Juraj Strossmayer Univ Osijek, Fac Med, Josipa Huttlera 4, Osijek 31000, Croatia
[3] Ruđer Bosković Inst, Div Mol Med, Lab Hereditary Canc, Bijenička Cesta 54, Zagreb 10000, Croatia
[4] Clin Hosp Ctr Zagreb, Kispatićeva 12, Zagreb 10000, Croatia
[5] Clin Hosp Ctr Zagreb, Dept Otorhinolaryngol & Head & Neck Surg, Maxillofacial Surg Unit, Kispatićeva Ulica 12, Zagreb 10000, Croatia
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 24期
关键词：
oral squamous cell carcinoma; oropharyngeal squamous cell carcinoma; survivin; BIRC5; biomarkers; SURVIVIN GENE; PROMOTER POLYMORPHISM; LUNG-CANCER; RISK; SUSCEPTIBILITY; VARIANTS; MUTATION; PROTEIN; HEAD; SNP;
D O I：
10.3390/ijms242417490
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Oral squamous cell carcinoma (OSCC) and oropharyngeal squamous cell carcinoma (OPSCC) are the most common types of cancers in the head and neck region (HNSCC). Despite very aggressive treatment modalities, the five-year survival rate has not changed for decades and is still around 60%. The search for potential specific biomarkers of aggressiveness or outcome indicators could be of great benefit in improving the treatment of these patients. One of the potential biomarkers is survivin, the protein product of the BIRC5 gene. In this study, we investigated the occurrence of BIRC5 gene polymorphisms in 48 patients with OSCC and OPSCC compared with healthy controls. A total of 18 polymorphisms were found, 11 of which occurred in HNSCC with a minor allele frequency (MAF) of more than 5%. Five polymorphisms (rs3764383, rs9904341, rs2071214, rs2239680, rs2661694) were significantly associated with tumor size, tumor stage, and advanced regional disease, but had no impact on survival.
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页数：11
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