Bone mass, fracture risk, and associated factors in postmenopausal women living with HIV

被引:0
|
作者
Leite-Silva, Paula R. [1 ,2 ,3 ]
Pinheiro, Rebeca S. [3 ]
Barbosa-Ferreira, Joao M. B. [2 ,4 ]
Balieiro, Antonio [5 ,6 ]
Sabido, Meritxell
Lacerda, Marcus V. G. [1 ,2 ,6 ]
Chaves, Yury O. [5 ,6 ]
Nogueira, Paulo A. [5 ,6 ]
Benzaken, Adele S. [1 ,6 ]
机构
[1] Univ Estado Amazonas, Pos Graduacao Med Trop, Manaus, Brazil
[2] Univ Estado Amazonas, Manaus, Brazil
[3] Univ Fed Amazonas, Pos Graduacao Imunol Bas & Aplicada, Manaus, Brazil
[4] Fundacao Hosp Coracao Francisca Mendes, Manaus, Brazil
[5] Fundacao Med Trop Dr Heitor Vieira Dourado, Manaus, Brazil
[6] Inst Leonidas & Maria Deane Fiocruz, Manaus, Brazil
关键词
Bone mineral density; Fracture risk assessment; Human immunodeficiency virus; Menopause; Osteoporosis; MINERAL DENSITY; ANTIRETROVIRAL THERAPY; LIFE EXPECTANCY; OSTEOPOROSIS; INFECTION; MICROARCHITECTURE; MANAGEMENT; DIAGNOSIS; ESTROGEN; BURDEN;
D O I
10.1097/GME.0000000000002293
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: The aim of this study was to assess the prevalence of low bone mass (osteopenia/osteoporosis), the factors associated with low bone mass, and the risk of fractures in Brazilian postmenopausal women living with HIV (WLH) in the Amazon regionMethods: This is a cohort study with a cross-sectional assessment at baseline conducted between March 2021 to August 2022 with 100 postmenopausal WLH undergoing antiretroviral therapy (ART) between 45 and 60 years of age and 100 age-matched HIV-negative women. Data on bone mineral density in the lumbar spine (LS) and femoral neck (FN) were collected using dual x-ray absorptiometry and the 10-year risk of hip and major osteoporotic fractures was assessed using the Fracture Risk Assessment tool (FRAX).Results: The age of menopause onset occurred earlier in WLH (P < 0.001). No differences in prevalence of osteoporosis and osteopenia in LS and FN were observed except for a lower T score in FN in WLH (P = 0.039). The FRAX for major osteoporotic fracture and hip fracture were low in both groups, despite the mean of both FRAX scores was higher in WLH (P < 0.001). Multivariate analysis showed that years since menopause onset, higher body mass index and higher FRAX major osteoporotic fracture were associated with the WLH group, while a higher frequency of physical activity was registered in the HIV-negative group. Multivariate analysis also showed that in WLH, a lower T score in FN was associated with years since menopause onset and body mass index and that the number of years since menopause onset was associated with a lower T score in the LS and a higher score in the FRAX hip fracture.Conclusions: Our findings show a high prevalence of low bone mass (osteopenia/osteoporosis) in Brazilian postmenopausal women from the Amazon region. Women living with HIV have higher FRAX scores than HIV-negative women and a lower T score in the FN.
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页码:46 / 51
页数:6
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