Dynamic metabolism during early mammalian embryogenesis

被引：5

作者：

Zhao, Jing ^{[1
]}

Wang, Wenjie

Zhang, Ling ^{[1
]}

Zhang, Jia ^{[2
,3
]}

Sturmey, Roger ^{[4
]}

Zhang, Jin ^{[1
,2
,3
]}

机构：

[1] Zhejiang Univ, Liangzhu Lab, Hangzhou 311121, Peoples R China

[2] Zhejiang Univ, Affiliated Hosp 1, Ctr Stem Cell & Regenerat Med, Dept Basic Med Sci, Hangzhou 310058, Peoples R China

[3] Zhejiang Univ, Affiliated Hosp 1, Bone Marrow Transplantat Ctr, Hangzhou 310058, Peoples R China

[4] Univ Hull, Biomed Inst Multimorbid, Hull York Med Sch, Kingston Upon Hull HU6 7RX, England

来源：

DEVELOPMENT | 2023年 / 150卷 / 20期

基金：

中国国家自然科学基金;

关键词：

Metabolism; Embryo development; Oocyte; Epigenetics; Zygote genome activation; DNA METHYLATION; MOUSE EMBRYOS; AMINO-ACIDS; FATTY-ACIDS; PREIMPLANTATION EMBRYOS; GLUCOSE-METABOLISM; LIPID-METABOLISM; PYRUVATE UPTAKE; ACETYL-COA; STEM-CELLS;

D O I：

10.1242/dev.202148

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Dynamic metabolism is exhibited by early mammalian embryos to support changing cell fates during development. It is widely acknowledged that metabolic pathways not only satisfy cellular energetic demands, but also play pivotal roles in the process of cell signalling, gene regulation, cell proliferation and differentiation. Recently, various new technological advances have been made in metabolomics and computational analysis, deepening our understanding of the crucial role of dynamic metabolism during early mammalian embryogenesis. In this Review, we summarize recent studies on oocyte and embryo metabolism and its regulation, with a particular focus on its association with key developmental events such as fertilization, zygote genome activation and cell fate determination. In addition, we discuss the mechanisms of certain metabolites that, in addition to serving as energy sources, contribute to epigenetic modifications.

引用

页数：10

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