Thiazolamide derivatives containing diphenyl ethers moiety: design, synthesis, fungicidal activity and docking study

被引：4

作者：

Yan, Zhongzhong ^{[1
,2
]}

Gao, Yusheng ^{[1
]}

Yang, Ziyu ^{[1
]}

Yu, Bolin ^{[1
]}

Zhao, Di ^{[1
]}

Li, Yuefeng ^{[1
]}

Cao, Lei ^{[1
]}

Qin, Mengyao ^{[1
]}

Li, Mengmeng ^{[1
]}

Jin, Feng ^{[1
,2
]}

机构：

[1] Anhui Univ Sci & Technol, Med Coll, Huainan 232001, Peoples R China

[2] Anhui Univ Sci & Technol, Key Lab Ind Dust Prevent & Control & Occupat Hlth, Minist Educ, Huainan 232001, Peoples R China

来源：

JOURNAL OF CHEMICAL SCIENCES | 2023年 / 135卷 / 03期

关键词：

Thiazolamide; Antifungal activity; Cytotoxicity; Molecular docking; ANTIFUNGAL ACTIVITY; NICOTINAMIDE DERIVATIVES; BIOLOGICAL EVALUATION; DISCOVERY; RESISTANCE; INHIBITOR;

D O I：

10.1007/s12039-023-02184-z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Some thiazolamide derivatives containing diphenyl ether moiety were designed, synthesized, and studied for their antifungal activity and cell cytotoxicity. Of these, several compounds II possessed excellent activity against Rhizoctonia solani, which was better than that of boscalid and comparable to thifluzamide. Besides, the cytotoxicity test showed that the optimal compound IIf had lower cytotoxicity than thifluzamide in general. Further, molecular docking could give a reasonable explanation for the high activity of the target compounds. The above results indicated that thiazolamide derivatives containing diphenyl ether moiety are valuable for in-depth study to obtain high-efficiency and low-toxicity green pesticides.

引用

页数：10

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