Underlying mechanisms and molecular targets of genistein in the management of type 2 diabetes mellitus and related complications

被引：5
|
作者：
Jiang, Tao [1 ,2 ]
Dong, Yuhe [1 ]
Zhu, Wanying [3 ]
Wu, Tong [3 ]
Chen, Linyan [4 ]
Cao, Yuantong [4 ]
Yu, Xi [4 ]
Peng, Ye [4 ]
Wang, Ling [4 ]
Xiao, Ying [4 ]
Zhong, Tian [4 ]
机构：
[1] Macau Univ Sci & Technol, Fac Med, Sch Pharm, Macao Sar, Peoples R China
[2] Zhuhai Coll Sci & Technol, Sch Pharm & Food Sci, Zhuhai, Guangdong, Peoples R China
[3] Macau Univ Sci & Technol, Fac Chinese Med, Macao Sar, Peoples R China
[4] Macau Univ Sci & Technol, Fac Med, Macao Sar, Peoples R China
来源：
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION | 2023年
关键词：
Genistein; hypoglycemia; oxidative stress; anti-inflammation; signaling pathway; IMPROVES AORTIC REACTIVITY; FRACTURE RISK; SIGNALING PATHWAY; MOUSE MODEL; HIGH-FAT; DIETARY GENISTEIN; HIGH GLUCOSE; IN-VITRO; INFLAMMATION; CANCER;
D O I：
10.1080/10408398.2023.2240886
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Diabetes mellitus (DM) is a chronic metabolic disease caused by a complex interaction of genetic and environmental factors and is characterized by persistent hyperglycemia. Long-term hyperglycemia can cause macrovascular and microvascular damage, and compromise the heart, brain, kidney, peripheral nerves, eyes and other organs, leading to serious complications. Genistein, a phytoestrogen derived from soybean, is known for its various biological activities and therapeutic properties. Recent studies found that genistein not only has hypoglycemic activity but can also decrease insulin resistance. In addition, genistein has particular activity in the prevention and treatment of diabetic complications, such as nephropathy, cardiovascular disease, osteoarthrosis, encephalopathy and retinopathy. Therefore, the purpose of this review is to summarize the latest medical research and progress of genistein in DM and related complications and highlights its potential molecular mechanisms and therapeutic targets. Meanwhile, evidence is provided for the development and application of genistein as a potential drug or functional food in the prevention and treatment of diabetes and its related complications.
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收藏
页数：13
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