Synthesis of Aryl Amides from Acyl-Bunte Salts and Aryl Azides

被引：5

作者：

Chen, Li-Jia ^{[1
]}

Kuo, Chia-Jou ^{[1
]}

Liang, Chien-Fu ^{[1
]}

机构：

[1] Natl Chung Hsing Univ, Dept Chem, Taichung 402, Taiwan

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 88卷 / 15期

关键词：

ONE-POT SYNTHESIS; CARBOXYLIC-ACIDS; REDUCTIVE AMIDATION; BOND FORMATION; THIOACIDS; ALDEHYDES; ALCOHOLS; THIOESTERS; ODORLESS; CARBENE;

D O I：

10.1021/acs.joc.3c00477

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In this study, we developed an efficient method for thesynthesisof aryl amides from sodium thiosulfate pentahydrate, organic anhydrides,and aryl azides. Sodium thiosulfate may be used as the sulfur source,which reacts with anhydrides to generate acyl-Bunte salt; this saltreacts with aryl azides via the in situ generation of thiocarboxylate. Using our method, we successfullysynthesized a key bioactive compound. The advantages of one-pot two-stepreactions include operational simplicity, structurally diverse productswith favorable yields, use of less toxic odorless reagents, and easyapplicability to large-scale operations.

引用

页码：10501 / 10507

页数：7

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