Antioxidant effects of Bifidobacterium longum T37a in mice weight loss and aging model induced by D-galactose

被引：1

作者：

Wang, Ya ^{[1
,2
]}

Wang, Jiahui ^{[1
,2
,3
]}

Li, Hehai ^{[1
]}

Lao, Jianlong ^{[1
]}

Jia, Dan ^{[1
,3
]}

Liu, Junlong ^{[3
]}

Wang, Jinming ^{[3
]}

Luo, Jianxun ^{[3
]}

Guan, Guiquan ^{[3
]}

Yin, Hong ^{[3
]}

Li, Youquan ^{[1
,3
]}

机构：

[1] Guangdong Ocean Univ, Coll Coastal Agr Sci, Dept Vet Med, Zhanjiang 524088, Guangdong, Peoples R China

[2] Lanzhou Univ Technol, Coll Life Sci & Engn, Lanzhou 730050, Peoples R China

[3] Chinese Acad Agr Sci, Lanzhou Vet Res Inst, State Key Lab Vet Etiol Biol, Key Lab Vet Parasitol Gansu Prov, Lanzhou 730046, Peoples R China

来源：

BMC MICROBIOLOGY | 2023年 / 23卷 / 01期

关键词：

Bifidobacterium longum; Antioxidant; Anti-aging; MECHANISMS;

D O I：

10.1186/s12866-023-02846-5

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

BackgroundProbiotics can reduce free radical scavenging rate and oxidative damage, and improve activity of crucial antioxidative enzymes in host cells. This study aimed to isolate Bifidobacterium spp. from faeces of babies, and investigate the antioxidant effects of the Bif. longum T37a in mice weight loss and aging model induced by D-galactose.ResultsT37a have good antioxidant properties in the DPPH assay and anti-lipid peroxidation test. Compared with the model group, T37a low group significantly increased the thymus index and the levels of T-AOC and GSH-Px of mice. T37a high group significantly decreased the spleen and liver index of mice and the levels of MDA in liver, significantly increased in liver HDL-C levels, and decreased LDL-C in liver.ConclusionsT37a may be an anti-aging and weight-loss probiotics for its antioxidant capacity, and it is necessary to study further the molecular mechanism of T37a as antioxidant.

引用

页数：10

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