Comprehensive Study of Components and Antimicrobial Properties of Essential Oil Extracted from Carum carvi L. Seeds

被引：1
|
作者：
Liu, Changhai [1 ,2 ]
Cheng, Feng [1 ,2 ]
Aisa, Haji Akber [1 ]
Maiwulanjiang, Maitinuer [1 ]
机构：
[1] Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Xinjiang Key Lab Plant Resources & Nat Prod Chem, Urumqi 830011, Peoples R China
[2] Univ Chinese Acad Sci, Coll Chem Sci, Beijing 100039, Peoples R China
来源：
ANTIBIOTICS-BASEL | 2023年 / 12卷 / 03期
基金：
中国科学院西部之光基金;
关键词：
Carum carvi L; essential oil; MRSA; GC-Q-TOF-MS; metabolomics; RESISTANT STAPHYLOCOCCUS-AUREUS; BIOFILM; MRSA;
D O I：
10.3390/antibiotics12030591
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Carum carvi L. belongs to the Apiaceae family and is widely used as a vegetable, food spice, preservative, and herbal medicine. This study investigated the impact of essential oil extracted from Carum carvi L. seeds (CEO) on methicillin-resistant Staphylococcus aureus (MRSA) and its possible action mechanism. The dominant chemical components of CEO determined by GC-MS were carvone and limonene. It was observed that CEO had a considerable inhibitory effect against the growth of planktonic bacteria and biofilm in MRSA cells. Untargeted metabolomics based on GC-Q-TOF-MS was used to analyze the possible mechanism of the interaction of MRSA with CEO. It was determined that there were 63 different metabolites based on fold change values greater than 1.5 or less than 1.5, p < 0.05, VIP > 1, which demonstrated amino acid metabolism in MRSA was significantly affected by CEO. In conclusion, CEO has a potent antimicrobial property and has promising potential for use in food and drugs.
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页数：11
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