Redefining Cancer Therapy: Toward BCL-XL/BCL-2 Dual Inhibitors with Diminished Platelet Toxicity

被引:1
|
作者
Kargbo, Robert B. [1 ]
机构
[1] Usona Inst, Fitchburg, WI 53711 USA
来源
ACS MEDICINAL CHEMISTRY LETTERS | 2023年 / 14卷 / 09期
关键词
D O I
10.1021/acsmedchemlett.3c00357
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
This Patent Highlight focuses on the development of Bcl-xL/Bcl-2 dual inhibitors with minimized platelet toxicity to improve cancer treatment strategies. Acknowledging the critical role of antiapoptotic Bcl-2 family proteins in cancer pathogenesis, the paper reviews various inhibitors, notably venetoclax. Despite its success, resistance due to Bcl-xL upregulation prompted interest in dual inhibitors like ABT-263. However, their use often incurs platelet toxicity. Hence, this Patent Highlight showcases the synthesis of new compounds that could maintain potent antitumor effects while preserving platelet viability. This novel approach could redefine cancer therapy, offering more effective treatment for Bcl-2-driven cancers.
引用
收藏
页码:1156 / 1158
页数:3
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