Dasatinib-induced follicular lymphoid hyperplasia, an entity to know

被引：0

作者：

Phelippeau, Mona ^{[1
]}

Lefebvre, Christine ^{[2
]}

Jacob, Marie-Christine ^{[3
]}

Syrykh, Charlotte ^{[4
]}

Ghelfi, Julien ^{[5
]}

Carras, Sylvain ^{[2
,6
,7
]}

Laurent, Camille ^{[4
]}

Molina, Lysiane ^{[7
]}

Valmary-Degano, Severine ^{[1
,6
]}

机构：

[1] CHU Grenoble Alpes, Serv Anat & Cytol Pathol, F-38000 Grenoble, France

[2] CHU Grenoble Alpes, Lab Hematol, F-38000 Grenoble, France

[3] CHU Grenoble Alpes, Lab Immunol, F-38000 Grenoble, France

[4] Inst Univ Canc Toulouse, Toulouse Oncopole, Serv Anat & Cytol pathol, F-31000 Toulouse, France

[5] CHU Grenoble Alpes, Dept Radiol, F-38000 Grenoble, France

[6] Univ Grenoble Alpes, Inst avancee Biosci IAB, Inserm U1209, CNRS UMR5309, F-38000 Grenoble, France

[7] Ctr Hosp Univ Grenoble Alpes, Serv dhematol, F-38000 Grenoble, France

来源：

ANNALES DE PATHOLOGIE | 2023年 / 43卷 / 01期

关键词：

Follicular lymphoid hyperplasia; Dasatinib; Side effects; Drug induced lymphadenopathy; TYROSINE KINASE INHIBITOR; LEUKEMIA;

D O I：

10.1016/j.annpat.2022.09.005

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Follicular lymphoid hyperplasia induced by dasatinib is an entity recently described. It is sometimes difficult to rule out the diagnostic of small B-cell lymphoma. Usually, the node is swollen, with follicular architecture conserved, composed by germinal centers with variable size and shape, with a hight number of mitoses and tingible bodies macrophages inside. Follicular lymphoid hyperplasia is isolated or associated with multiple reactive patterns. The immunohistochemical profil of germinal centers is CD20+, CD10+, BCL6+, BCL2-. Swollen node disappears in a short time after dasatinib discontinuation. Clinicians and pathologists need to be aware of this entity, so as not to avoid mistakenly suspect lymphoma when lymphadenopathy occurs in a patient with chronic myeloid leukemia treated with dasatinib. (c) 2022 Elsevier Masson SAS. All rights reserved.

引用

页码：45 / 51

页数：7

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