Aberrant O-glycosylation of IgA1 and complement in IgA nephropathy: Glomerular immunodeposits of patients with histologically active disease exhibit elevated colocalization of IgA and complement C3

被引:0
|
作者
Novak, Lea [1 ,2 ]
Hall, Stacy D. [1 ,2 ]
Gurganus, Graham L. [1 ,2 ]
Rizk, Dana V. [1 ,2 ]
Julian, Bruce A. [1 ,2 ]
Haas, Mark [3 ]
Novak, Jan [1 ,2 ]
机构
[1] Univ Alabama Birmingham, Dept Microbiol, Birmingham, AL USA
[2] Univ Alabama Birmingham, Dept Med, Birmingham, AL USA
[3] Cedars Sinai Med Ctr, Dept Pathol, Los Angeles, CA USA
关键词
D O I
暂无
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
P105
引用
收藏
页码:1002 / 1003
页数:2
相关论文
共 50 条
  • [31] Initiation of Clustered O-glycosylation of IgA1 by GalNAc-transferases in IgA Nephropathy: New Methods for Complex Product Analysis
    Stewart, Tyler
    Takahashi, Kazuo
    Bian, Qi
    Huang, Zhiqiang
    Raska, Milan
    Renfrow, Matthew
    Novak, Jan
    GLYCOBIOLOGY, 2014, 24 (11) : 1203 - 1203
  • [32] IgA Nephropathy Caused by Unusual Polymerization of IgA1 with Aberrant N-Glycosylation in a Patient with Monoclonal Immunoglobulin Deposition Disease
    Narimatsu, Yoshiki
    Kuno, Atsushi
    Ito, Hiromi
    Kaji, Hiroyuki
    Kaneko, Syuzo
    Usui, Joichi
    Yamagata, Kunihiro
    Narimatsu, Hisashi
    PLOS ONE, 2014, 9 (03):
  • [33] Differences in colocalization of IgA and complement C3 in the immune complexes (IC) of renal biopsies from IgA nephropathy (IgAN) patients with mild and severe renal tissue injury
    Novak, L
    Novak, J
    Vernerova, Z
    Rychlik, I
    Stejskal, J
    Cook, WJ
    Keyser, KT
    Mestecky, J
    Julian, BA
    LABORATORY INVESTIGATION, 2005, 85 : 269A - 269A
  • [34] Differences in colocalization of IgA and complement C3 in the immune complexes (IC) of renal biopsies from IgA nephropathy (IgAN) patients with mild and severe renal tissue injury
    Novak, L
    Novak, J
    Vernerova, Z
    Rychlik, I
    Stejskal, J
    Cook, WJ
    Keyser, KT
    Mestechy, J
    Julian, BA
    MODERN PATHOLOGY, 2005, 18 : 269A - 269A
  • [35] Complement C3 Contributes to the Pathogenicity of Galactose-Deficient IgA1-Containing Immune Complexes in IgA Nephropathy
    Hall, Stacy D.
    Gurganus, Graham
    Huang Zhi qiang
    Knoppova, Barbora
    Nakazawa, Shigeaki
    Maillard, Nicolas
    Moldoveanu, Zina
    Rizk, Dana, V
    Julian, Bruce A.
    Renfrow, Matthew B.
    Green, Todd J.
    Novak, Jan
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2024, 35 (10):
  • [36] Intraglomerular synthesis of complement C3 and its activation products in IgA nephropathy
    Abe, K
    Miyazaki, M
    Koji, T
    Furusu, A
    Shioshita, K
    Tsukasaki, S
    Ozono, Y
    Harada, T
    Sakai, H
    Kohno, S
    NEPHRON, 2001, 87 (03): : 231 - 239
  • [37] Activated complement C3: A potentially novel predictor of progressive IgA nephropathy
    Zwirner, J
    Burg, M
    Schulze, M
    Brunkhorst, R
    Gotze, O
    Koch, KM
    Floege, J
    KIDNEY INTERNATIONAL, 1997, 51 (04) : 1257 - 1264
  • [38] Mesangial C3 Deposition, Complement-Associated Variant, and Disease Progression in IgA Nephropathy
    Kang, Yuqi
    Xu, Boyang
    Shi, Sufang
    Zhou, Xujie
    Chen, Pei
    Liu, Lijun
    Li, Yebei
    Leng, Yueqi
    Lv, Jicheng
    Zhu, Li
    Zhang, Hong
    CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2023, 18 (12): : 1583 - 1591
  • [39] IgA nephropathy: an autoimmune kidney disease with pathogenic circulatory immune complexes consisting of polymeric IgA1 with galactose-deficient and minimally sialylated O-glycans, IgG, and complement C3
    Hall, Stacy
    Coffee, Sarah
    Huang, Zhi-Qiang
    Maillard, Nicolas
    Moldoveanu, Zina
    Hargett, Audra A.
    Rizk, Dana V.
    Julian, Bruce A.
    Renfrow, Matthew B.
    Novak, Jan
    GLYCOBIOLOGY, 2022, 32 (11) : 974 - 974
  • [40] Aberrant O-glycosylation and anti-glycan antibodies in an autoimmune disease IgA nephropathy and breast adenocarcinoma
    Horynova, Milada Stuchlova
    Raska, Milan
    Clausen, Henrik
    Novak, Jan
    CELLULAR AND MOLECULAR LIFE SCIENCES, 2013, 70 (05) : 829 - 839