Tailored Drug Delivery Platforms: Stimulus-Responsive Core-Shell Structured Nanocarriers

Core-shell structured nanocarriers have come into the scientific spotlight in recent years due to their intriguing properties and wide applications in materials chemistry, biology, and biomedicine. Tailored core-shell structures to achieve desired performance have emerged as a research frontier in the development of smart drug delivery system. However, systematic reviews on the design and loading/release mechanisms of stimulus-responsive core-shell structured nanocarriers are uncommon. This review starts with the categories of core-shell structured nanocarriers with different means of drug payload, and then highlights the controlled release mechanism realized through stimulus-response processes triggered under different environments. Finally, some multifaceted perspectives on the design of core-shell structured materials as drug carriers are addressed. This work aims to provide new enlightenments and prospects in the drug delivery field for further developing advanced and smart nanocarriers. This paper demonstrates that versatilities of drug delivery means achieved by the design of core-shell structured nanocarriers, and the realization of a drug release profile with a stimulus-responsive process. Multifaceted prospectives on the design of core-shell structured nanocarriers are addressed, paving the way for the further development of advanced and smart nanocarriers.image