Stimulus-Responsive Hydrogel for Ophthalmic Drug Delivery

被引：46
|
作者：
Lin, Deqing [1 ,2 ]
Lei, Lei [1 ,2 ]
Shi, Shuai [1 ,2 ]
Li, Xingyi [1 ,2 ]
机构：
[1] Wenzhou Med Univ, Sch Ophthalmol & Optometry, Inst Biomed Engn, 270 Xueyuan Rd, Wenzhou 325027, Peoples R China
[2] Wenzhou Med Univ, Eye Hosp, 270 Xueyuan Rd, Wenzhou 325027, Peoples R China
来源：
MACROMOLECULAR BIOSCIENCE | 2019年 / 19卷 / 06期
基金：
中国国家自然科学基金;
关键词：
drug deivlery; hydrogel; ophthalmic; BLOCK-COPOLYMER HYDROGELS; IN-VIVO EVALUATION; SITU GELLING SYSTEMS; OCULAR DELIVERY; SUPRAMOLECULAR HYDROGEL; GELLAN GUM; HYDROXYPROPYL METHYLCELLULOSE; ANTIINFLAMMATORY DRUG; MECHANICAL-PROPERTIES; INJECTABLE HYDROGELS;
D O I：
10.1002/mabi.201900001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Blindness and vision impairment are major global health problems. Effective ophthalmic drug delivery poses a significant challenge because of protective physiological barriers and various biological clearance mechanisms that result in extremely low ocular bioavailability. Over the past several decades, several safe and effective ophthalmic drug delivery approaches have been promoted to combat these problems and to improve ocular bioavailability. Among these approaches, the stimulus-responsive hydrogel for topical drug delivery has gained increasing attention because of its prolonged drug retention at the local site and enhanced ocular bioavailability. This review summarizes and presents recent advances and perspectives of a stimulus-responsive hydrogel for ophthalmic drug delivery.
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页数：12
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