Current management of xerostomia in head and neck cancer patients

被引：8

作者：

Nathan, Cherie-Ann O. ^{[1
,2
]}

Asarkar, Ameya A. ^{[1
]}

Entezami, Payam ^{[1
,2
]}

Corry, June ^{[3
]}

Strojan, Primoz ^{[4
]}

Vander Poorten, Vincent ^{[5
,6
]}

Makitie, Antti ^{[7
]}

Eisbruch, Avraham ^{[8
]}

Robbins, K. T. ^{[9
]}

Smee, Robert ^{[10
]}

St John, Maie ^{[11
]}

Chiesa-Estomba, Carlos ^{[12
]}

Winter, Stuart C. ^{[13
]}

Beitler, Jonathan J. ^{[14
]}

Ferlito, Alfio ^{[15
]}

机构：

[1] LSU Hlth Sci Ctr, Dept Otolaryngol Head & Neck Surg, Shreveport, LA 70112 USA

[2] Overton Brooks VA Med Ctr, Surg Serv, Otolaryngol Sect, Shreveport, LA USA

[3] Genesiscare St Vincents Hosp, Dept Radiat Oncol, Melbourne, Vic, Australia

[4] Inst Oncol, Dept Radiat Oncol, Ljubljana, Slovenia

[5] Univ Hosp Leuven, Otorhinolaryngol Head & Neck Surg, Leuven, Belgium

[6] Katholieke Univ Leuven, Dept Oncol, Sect Head & Neck Oncol, Leuven, Belgium

[7] Univ Helsinki, Helsinki Univ Hosp, Dept Otorhinolaryngol Head & Neck Surg, Helsinki, Finland

[8] Univ Michigan, Dept Radiat Oncol, Ann Arbor, MI USA

[9] Southern Illinois Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Springfield, IL USA

[10] Prince Wales Canc Ctr, Dept Radiat Oncol, Sydney, NSW, Australia

[11] UCLA, Dept Otolaryngol Head & Neck Surg, Los Angeles, CA USA

[12] Deusto Univ, Donostia Univ Hosp, Biodonostia Res Inst, Otorhinolaryngol Head & Neck Dept, Bilbao, Spain

[13] Univ Oxford, Nuffield Dept Surg Sci, Oxford, England

[14] Camden FD, Camden, ME USA

[15] Int Head & Neck Sci Grp, Padua, Italy

来源：

AMERICAN JOURNAL OF OTOLARYNGOLOGY | 2023年 / 44卷 / 04期

关键词：

Xerostomia; Radiation therapy; Head and neck cancers; Salivary glands; Submandibular glands; RADIATION-INDUCED XEROSTOMIA; SUBMANDIBULAR-GLAND TRANSFER; ELECTRICAL NERVE-STIMULATION; SQUAMOUS-CELL CARCINOMAS; MESENCHYMAL STEM-CELLS; SALIVARY FLOW-RATE; LONG-TERM; POSTRADIATION XEROSTOMIA; CONCOMITANT PILOCARPINE; RADIOTHERAPY;

D O I：

10.1016/j.amjoto.2023.103867

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Radiotherapy (RT) continues to play a key role in the management of head and neck cancer (HNC). Xerostomia remains a principal detriment to the quality of life (QoL) for 80 % of surviving patients receiving head and neck radiation. Radiation-induced injury to the salivary glands is dose-dependent, and thus efforts have been focused on decreasing radiation to the salivary glands. Decreased saliva production reduces both short-term and long-term quality of life in head and neck survivors by impacting on taste and contributing to dysphagia. Several radioprotective agents to the salivary gland have been investigated. Although not widely practiced, surgical transfer of the submandibular gland prior to RT is the mainstay of surgical options in preventing xerostomia. This review focuses on the strategies to improve xerostomia following radiation therapy in head and neck cancers.

引用

页数：6

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