MouseVUER: video based open-source system for laboratory mouse home-cage monitoring

被引：2
|
作者：
Salem, Ghadi [1 ]
Cope, Niall [2 ]
Garmendia, Marcial [1 ]
Pu, Alex [2 ]
Somenhalli, Abhishek [1 ]
Krynitsky, Jonathan [1 ]
Cubert, Noah [1 ]
Jones, Thomas [1 ]
Dold, George [3 ]
Fletcher, Anthony [4 ]
Kravitz, Alexxai [5 ]
Pohida, Thomas [1 ]
Dennis, John [6 ]
机构：
[1] Natl Inst Biomed Imaging & Bioengn, Instrumentat Dev & Engn Applicat Solut, NIH, Bethesda, MD 20892 USA
[2] US DOE, Oak Ridge Inst Sci & Educ ORISE, Oak Ridge, TN USA
[3] Natl Inst Mental Hlth, Sect Instrumentat, NIH, Bethesda, MD USA
[4] NHLBI, Sci Informat Off, NIH, Bethesda, MD USA
[5] Washington Univ St Louis, Dept Psychiat, St Louis, MO USA
[6] US FDA, Div Vet Serv, Ctr Biol Evaluat & Res, Silver Spring, MD USA
来源：
SCIENTIFIC REPORTS | 2024年 / 14卷 / 01期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/s41598-024-52788-9
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Video monitoring of mice in the home-cage reveals behavior profiles without the disruptions caused by specialized test setups and makes it possible to quantify changes in behavior patterns continually over long time frames. Several commercial home-cage monitoring systems are available with varying costs and capabilities; however there are currently no open-source systems for home-cage monitoring. We present an open-source system for top-down video monitoring of research mice in a slightly modified home-cage. The system is designed for integration with Allentown NexGen ventilated racks and allows unobstructed view of up to three mice, but can also be operated outside the rack. The system has an easy to duplicate and assemble home-cage design along with a video acquisition solution. The system utilizes a depth video camera, and we demonstrate the robustness of depth video for home-cage mice monitoring. For researchers without access to Allentown NexGen ventilated racks, we provide designs and assembly instructions for a standalone non-ventilated rack solution that holds three systems for more compact and efficient housing. We make all the design files, along with detailed assembly and installation instructions, available on the project webpage (https://github.com/NIH-CIT-OIR-SPIS/MouseVUER).
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页数：13
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