Synergistic interaction of Cu(II) with caffeic acid and chlorogenic acid in a-glucosidase inhibition

被引:2
|
作者
Tang, Lihua [2 ,3 ]
Guan, Qinhao [2 ,3 ]
Zhang, Liangliang [4 ,5 ]
Xu, Man [1 ,2 ,3 ]
Zhang, Meng [6 ]
Khan, Mohd Shahnawaz [7 ]
机构
[1] CAF, Key Lab Biomass Energy & Mat, Inst Chem Ind Forest Prod, Nanjing, Peoples R China
[2] Natl Forestry & Grassland Adm, Inst Chem Ind Forest Prod, Natl Engn Res Ctr Low Carbon Proc & Utilizat Fores, Jiangsu Coinnovat Ctr Efficient Proc & Utilizat Fo, Nanjing, Jiangsu, Peoples R China
[3] Nanjing Forestry Univ, Coinnovat Ctr Efficient Proc & Utilizat Forest Res, Nanjing, Peoples R China
[4] Huaqiao Univ, Acad Adv Carbon Convers Technol, Xiamen, Peoples R China
[5] Huaqiao Univ, Fujian Prov Key Lab Biomass Low Carbon Convers, Xiamen, Peoples R China
[6] Yancheng Teachers Univ, Sch Wetlands, Jiangsu Key Lab Bioresources Saline Soils, Yancheng, Peoples R China
[7] King Saud Univ, Dept Biochem, Riyadh, Saudi Arabia
关键词
alpha-Glucosidase; phenolic acid; copper ion; polyphenol-protein interaction; fluorescence quenching; RESONANCE ENERGY-TRANSFER; ALPHA-GLUCOSIDASE; IN-VIVO; FLUORESCENCE; MECHANISM; PROTEIN;
D O I
10.1002/jsfa.12955
中图分类号
S [农业科学];
学科分类号
09 ;
摘要
BACKGROUND: Phenolic acids are widespread in foods and are beneficial to human health. However, the role of metal ions in influencing the binding of proteins with phenolic acids that contain the same parent nucleus structure remains unclear. This study investigated the inhibitory effect of caffeic acid (CA) and chlorogenic acid (CHA) on alpha-glucosidase and the biological effect of copper on this process. RESULTS: It was found that the esterification of CA with quinic acid could increase the fluorescence quenching, conformational change, and inhibitory effect of CHA on alpha-glucosidase. Copper ions reduced their fluorescence quenching and conformationchanging ability by binding to the neighboring phenolic hydroxyl group but also increased their ability to alter secondary structure and to inhibit alpha-glucosidase and in vitro anti-glycation. CONCLUSION: Overall, this study shows that the binding of copper ions to the phenolic hydroxyl group adjacent to CA and CHA synergistically inhibited alpha-glucosidase. The findings will offer a theoretical basis for investigating the properties of metal ions and phenolic acid in food chemistry and their potential applications in the prevention and treatment of diabetes mellitus. (c) 2023 Society of Chemical Industry.
引用
收藏
页码:518 / 529
页数:12
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