A Retrospective Study of the Safety and Immunogenicity of MVC-COV1901 Vaccine for People Living with HIV

被引：4

作者：

Cheng, Shu-Hsing ^{[1
,2
]}

Lien, Chia En ^{[3
,4
]}

Hsieh, Szu-Min ^{[5
,6
]}

Cheng, Chien-Yu ^{[1
,4
]}

Liu, Wang-Da ^{[5
,7
]}

Lo, Ching-Lung ^{[8
,9
]}

Ko, Wen-Chien ^{[8
,9
]}

Chen, Yen-Hsu ^{[10
,11
,12
]}

Huang, Ching-Tai ^{[13
,14
]}

Chang, Hsiao-Ting ^{[15
,16
]}

Hwang, Shinn-Jang ^{[15
,16
]}

Wang, Ning-Chi ^{[17
]}

Liu, Ming-Che ^{[18
,19
]}

Lee, Yu-Lin ^{[20
,21
]}

Tai, I-Chen ^{[3
]}

Estrada, Josue Antonio Garcia ^{[3
]}

Lin, Tzou-Yien ^{[14
,22
]}

Lee, Wen-Sen ^{[23
,24
]}

机构：

[1] Taoyuan Gen Hosp, Dept Infect Dis, Minist Hlth & Welf, Taoyuan 330, Taiwan

[2] Taipei Med Univ, Sch Publ Hlth, Taipei 110, Taiwan

[3] Medigen Vaccine Biol, Taipei 114, Taiwan

[4] Natl Yang Ming Chiao Tung Univ, Inst Publ Hlth, Coll Med, Taipei 112, Taiwan

[5] Natl Taiwan Univ Hosp, Dept Internal Med, Div Infect Dis, Taipei 100, Taiwan

[6] Natl Taiwan Univ, Coll Med, Taipei 106, Taiwan

[7] Natl Taiwan Univ, Dept Med, Canc Ctr, Taipei 100, Taiwan

[8] Natl Cheng Kung Univ Hosp, Dept Internal Med, Tainan 704, Taiwan

[9] Natl Cheng Kung Univ, Coll Med, Dept Med, Tainan 701, Taiwan

[10] Kaohsiung Med Univ Hosp, Dept Internal Med, Div Infect Dis, Kaohsiung 807, Taiwan

[11] Kaohsiung Med Univ, Grad Inst Med, Sepsis Res Ctr, Sch Med, Kaohsiung 807, Taiwan

[12] Kaohsiung Med Univ, Ctr Trop Med & Infect Dis, Kaohsiung 807, Taiwan

[13] Chang Gung Mem Hosp, Dept Infect Dis, Taoyuan 333, Taiwan

[14] Chang Gung Univ, Coll Med, Taoyuan 333, Taiwan

[15] Taipei Vet Gen Hosp, Dept Family Med, Taipei 112, Taiwan

[16] Natl Yang Ming Chiao Tung Univ, Sch Med, Taipei 112, Taiwan

[17] Triserv Gen Hosp, Taipei 114, Taiwan

[18] Taipei Med Univ Hosp, Clin Res Ctr, Taipei 110, Taiwan

[19] Taipei Med Univ, Coll Oral Med, Sch Dent Technol, Taipei 110, Taiwan

[20] Changhua Christian Hosp, Dept Internal Med, Changhua 500, Taiwan

[21] Natl Chung Hsing Univ, Program Med Biotechnol, Taichung 402, Taiwan

[22] Chang Gung Mem Hosp, Dept Paediat, Taoyuan 333, Taiwan

[23] Taipei Med Univ, Wan Fang Hosp, Dept Internal Med, Div Infect Dis, Taipei 116, Taiwan

[24] Taipei Med Univ, Coll Med, Sch Med, Dept Internal Med, Taipei 110, Taiwan

来源：

VACCINES | 2023年 / 11卷 / 01期

关键词：

COVID-19; vaccine; CpG; 1018; S-2P protein; HIV; CD4; CD8; ratio; immunogenicity; HUMAN-IMMUNODEFICIENCY-VIRUS; HEPATITIS-B VACCINATION; T-CELL DIFFERENTIATION; ANTIBODY-RESPONSE; COVID-19; VACCINE; MESSENGER-RNA; SARS-COV-2; INFECTION; NUMBER; ADULTS;

D O I：

10.3390/vaccines11010018

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background: This study aimed to assess the safety and immunogenicity of MVC-COV1901, a recombinant COVID-19 protein vaccine, containing S-2P protein adjuvanted with CpG 1018 and aluminum hydroxide, for people living with HIV (PWH). Methods: A total of 57 PWH of >= 20 years of age who are on stable antiretroviral therapy were compared with 882 HIV-negative participants. Participants received two doses of MVC-COV1901 28 days apart. Results: No vaccine-related serious adverse events (SAEs) were recorded. Seroconversion rates (SCRs) of 100% and 99.8% were achieved in PWH and comparators, respectively, 28 days after the second dose. After adjusting for sex, age, BMI category, and comorbidity, the adjusted GMT ratio of comparator/PWH was 3.2 (95% CI 2.5-4). A higher CD4/CD8 ratio was associated with a higher GMT (R = 0.27, p = 0.039). MVC-COV1901 has shown robust safety but elicited weaker immune responses in PWH. Conclusions: Further investigations may be needed to determine whether PWH require distinct immunization strategies with improved immunogenicity. The main study is registered at ClinicalTrials.gov (NCT04695652).

引用

页数：14

共 50 条

[21] COVID-19 Vaccination in People Living with HIV (PLWH) in China: A Cross Sectional Study of Vaccine Hesitancy, Safety, and Immunogenicity
Liu, Ying
Han, Junyan
Li, Xin
Chen, Danying
Zhao, Xuesen
Qiu, Yaruo
Zhang, Leidan
Xiao, Jing
Li, Bei
Zhao, Hongxin
VACCINES, 2021, 9 (12)
[22] Safety and Immunogenicity of SARS-CoV-2 vaccines in people with HIV
Gonzalez de Aledo, Manuel
Canizares, Angelina
Vazquez-Rodriguez, Pilar
Castro, Angeles
Moldes, Luz
Lopez, Soledad
Miguez, Enrique
Bou, German
Mena, Alvaro
AIDS, 2022, 36 (05) : 691 - 695
[23] Safety and Immunogenicity of the Nonavalent Human Papillomavirus Vaccine in Women Living with HIV
Hidalgo-Tenorio, Carmen
Moya, Raquel
Omar, Mohamed
Munoz, Leopoldo
SamPedro, Antonio
Lopez-Hidalgo, Javier
Garcia-Vallecillos, Coral
Gomez-Ronquillo, Patricia
VACCINES, 2024, 12 (08)
[24] Immunogenicity and Safety of the Quadrivalent Human Papillomavirus Vaccine in Girls Living With HIV
Brophy, Jason
Bitnun, Ari
Alimenti, Ariane
Lapointe, Normand
Samson, Lindy
Read, Stanley
Karatzios, Christos
Dobson, Simon
Moses, Erin
Blitz, Sandra
Lipsky, Nancy-Grace
Ogilvie, Gina
Walmsley, Sharon
Raboud, Janet
Money, Deborah
PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2018, 37 (06) : 595 - 597
[25] Protection of hamsters challenged with SARS-CoV-2 after two doses of MVC-COV1901 vaccine followed by a single intranasal booster with nanoemulsion adjuvanted S-2P vaccine
Yi-Jiun Lin
Meei-Yun Lin
Ya-Shan Chuang
Luke Tzu-Chi Liu
Tsun-Yung Kuo
Charles Chen
Shyamala Ganesan
Ali Fattom
Vira Bitko
Chia-En Lien
Scientific Reports, 12
[26] Protection of hamsters challenged with SARS-CoV-2 after two doses of MVC-COV1901 vaccine followed by a single intranasal booster with nanoemulsion adjuvanted S-2P vaccine
Lin, Yi-Jiun
Lin, Meei-Yun
Chuang, Ya-Shan
Liu, Luke Tzu-Chi
Kuo, Tsun-Yung
Chen, Charles
Ganesan, Shyamala
Fattom, Ali
Bitko, Vira
Lien, Chia-En
SCIENTIFIC REPORTS, 2022, 12 (01)
[27] Immunogenicity of AZD1222 (ChAdOx1) SARS-CoV-2 vaccine in people living with HIV
Begovac, J.
Zekan, S.
Balent, N. Cetinic
Javoric, I.
Bogdanic, N.
Mikulic, R.
Rode, O. Dakovic
JOURNAL OF THE INTERNATIONAL AIDS SOCIETY, 2022, 25 : 216 - 217
[28] A randomized controlled trial of heterologous ChAdOx1 nCoV-19 and recombinant subunit vaccine MVC-COV1901 against COVID-19
Chen, Chih-Jung
Yang, Lan-Yan
Chang, Wei-Yang
Huang, Yhu-Chering
Chiu, Cheng-Hsun
Shih, Shin-Ru
Huang, Chung-Guei
Huang, Kuan-Ying A.
NATURE COMMUNICATIONS, 2022, 13 (01)
[29] A randomized controlled trial of heterologous ChAdOx1 nCoV-19 and recombinant subunit vaccine MVC-COV1901 against COVID-19
Chih-Jung Chen
Lan-Yan Yang
Wei-Yang Chang
Yhu-Chering Huang
Cheng-Hsun Chiu
Shin-Ru Shih
Chung-Guei Huang
Kuan-Ying A. Huang
Nature Communications, 13
[30] Covid-19 vaccine immunogenicity in people living with HIV-1
Nault, Lauriane
Marchitto, Lorie
Goyette, Guillaume
Tremblay-Sher, Daniel
Fortin, Claude
Martel-Laferriere, Valerie
Trottier, Benoit
Richard, Jonathan
Durand, Madeleine
Kaufmann, Daniel
Finzi, Andres
Tremblay, Cecile
VACCINE, 2022, 40 (26) : 3633 - 3637

← 1 2 3 4 5 →