Synthesis and cytotoxic activity of N-[(alkylsulfanyl)methyl]- and N-[(arylsulfanyl)methyl]benzamides

被引：0
|
作者：
Khairullina, R. R. [1 ]
Kuzmina, U. Sh. [2 ]
Yakupova, L. R. [1 ]
Vakhitova, Yu. V. [2 ]
机构：
[1] Russian Acad Sci, Inst Petrochem & Catalysis, Ufa Fed Res Ctr, 141 Prosp Oktyabrya, Ufa 450075, Russia
[2] Russian Acad Sci, Inst Biochem & Genet, Ufa Fed Res Ctr, 71 Prosp Oktyabrya, Ufa 450054, Russia
来源：
RUSSIAN CHEMICAL BULLETIN | 2023年 / 72卷 / 10期
关键词：
thiomethylation; aminobenzamides; thiols; paraformaldehyde; N-[(alkylsulfanyl)methyl]benzamides; N-[(arylsulfanyl)methyl]benzamides; cytotoxic activity; catalysis; TARGETED DRUG-DELIVERY; CATALYTIC THIOMETHYLATION; DERIVATIVES; POTENT; BIS(N; N-DIMETHYLAMINO)METHANE; 2-AMINOBENZAMIDE; ACTIVATOR;
D O I：
10.1007/s11172-023-4052-2
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A catalytic approach for the synthesis of N-[(alkylsulfanyl)methyl]- and N-[(arylsulfanyl)methyl]benzamides was developed via thiomethylation of 2-, 3- and 4-aminobenzamides with alkylthio- or arylthiomethanols. A moderate cytotoxic activity of 4-s[(heptylthio)methyl]aminobenzamide was established against a number of cell lines, with the most pronounced effect against the Jurkat leukemic T-cell line.
引用
收藏
页码：2501 / 2507
页数：7
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