Association Between Salivary Cytokines, Chemokines and Growth Factors and Salivary Gland Function in Children with Chronic Kidney Disease

被引:8
|
作者
Szulimowska, Julita [1 ]
Zalewska, Anna [1 ]
Taranta-Janusz, Katarzyna [2 ]
Marczuk-Kolada, Grazyna [3 ]
Zendzian-Piotrowska, Malgorzata [4 ]
Maciejczyk, Mateusz [4 ,5 ]
机构
[1] Med Univ Bialystok, Dept Restorat Dent, Bialystok, Poland
[2] Med Univ Bialystok, Dept Pediat & Nephrol, Bialystok, Poland
[3] Med Univ Bialystok, Dept Pedodont, Bialystok, Poland
[4] Med Univ Bialystok, Dept Hyg Epidemiol & Ergon, Bialystok, Poland
[5] Med Univ Bialystok, Dept Hyg Epidemiol & Ergon, 2c Mickiewicza St, PL-15233 Bialystok, Poland
关键词
chronic kidney disease; saliva; inflammation; salivary gland dysfunction; hyposalivation; PATHOGENESIS; UPDATE; CELLS; EPIDEMIOLOGY; INFLAMMATION; DIAGNOSIS; SECRETION; HEALTH; IL-6;
D O I
10.2147/JIR.S399786
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Introduction: Chronic kidney disease (CKD) is a systemic inflammatory disease that leads to multiple organ complications not only in the kidneys and the cardiovascular system, but also in the oral cavity. CKD children experience reduced saliva secretion (hyposalivation), which leads to increased incidence of dental caries and significant impairment of patients' quality of life. However, the causes of salivary gland dysfunction in children with CKD are unknown. The present study is the first to evaluate the inflammatory and anti-inflammatory profile in the saliva of children with CKD at different stages of renal failure with normal and reduced salivary gland function. Methods: Thirty children with CKD (age 9-16) and thirty age-and gender-matched healthy children were classified for the study. Salivary inflammatory and anti-inflammatory profile were assayed using the multiplex ELISA assay. Results: We demonstrated statistically significant changes in salivary pro-inflammatory (TTNF-alpha, down arrow IL-7), anti-inflammatory (TIL-10), Th1 (TINF-gamma, TIL-15), Th2 (TIL-4, TIL-5, TIL-6, TIL-9) and Th17 (IL-17) cytokines as well as chemokines (TMCP-1/CCL-2, TMIP-1 alpha/CCL3, down arrow MIP-1 beta/CCL4, down arrow EOTAXIN/CCL11) and growth factors (TG-CSF, TFGF) in unstimulated saliva of children with CKD compared to the controls. Although the evaluation of the salivary inflammatory profile does not indicate a particular dominance of any of the branches of the immune system, we observed a statistically significant increase in the concentration of all Th2 cytokines assayed. The multivariate regression analysis showed that the content of salivary cytokines, chemokines and growth factors depends on the secretory function of the salivary glands, ie, salivary flow, total protein concentration and amylase activity in the saliva. Salivary MIP-1 alpha/CCL3 was the most effective to differentiate children with CKD and hyposalivation from patients with normal saliva secretion. Discussion: Inflammation is involved in salivary gland dysfunction in children with CKD, although further studies on in vitro and in vivo models are necessary to confirm this hypothesis.
引用
收藏
页码:1103 / 1120
页数:18
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