SYNTHESIS, CHARACTERISATION, AND ANTICANCER AND ANTIOXIDANT ACTIVITIES OF NOVEL COMPLEXES OF PALLADIUM AND AN ORGANIC SCHIFF-BASE LIGAND

被引：5
|
作者：
Khalil, Muhammad H. [1 ]
Abdullah, Fuad O. [1 ,2 ]
机构：
[1] Salahaddin Univ Erbil, Coll Sci, Dept Chem, Erbil, Iraq
[2] Tishk Int Univ, Fac Pharm, Dept Pharmacognosy, Erbil, Iraq
来源：
BULLETIN OF THE CHEMICAL SOCIETY OF ETHIOPIA | 2024年 / 38卷 / 03期
关键词：
2-N-(Salicylidene) benzothiazole; 1; 10-Phenanthroline; Palladium mixed ligand complexes; Anticancer; Antioxidant activity; SPECTRAL CHARACTERIZATION; CU(II) COMPLEXES; METAL-COMPLEXES; COPPER(II); NICKEL(II);
D O I：
10.4314/bcse.v38i3.5
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Treatment of the Schiff base 2-N-(salicylidene) benzothiazole (SabtH) with palladium chloride afforded the neutral 2-N-(salicylidene) benzothiazole palladium(II) complex. This was then treated with one molar equivalent of either ethylenediamine or 1,10-phenanthroline, yielding the neutral mixed ligand complexes 1 and 2, respectively. The prepared organic ligand and its mixed ligand complexes were characterised via UV-Vis, FTIR, 1H-NMR, and 13C-NMR spectroscopy. The antiproliferative activities of 1 and 2 were tested against MCF-7 (breast) and HT -29 (colon) cancer cells using an MTT assay. 1 showed strong antiproliferative activity against both MCF-7 and HT -29 cancer cells, with IC50 values of 74.6 +/- 8.35 and 174 +/- 20.28 mu g/mL, respectively. In addition, 2 exhibited the maximum antioxidant activity, with an EC50 value of 1029 +/- 196.76 mu g/mL.
引用
收藏
页码：605 / 613
页数：9
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