Melodic maestros: Unraveling the role of miRNAs in the diagnosis, progression, and drug resistance of malignant pleural mesothelioma

被引：18

作者：

Abd-Elmawla, Mai A. ^{[1
]}

Mageed, Sherif S. Abdel ^{[2
]}

AL-Noshokaty, Tohada M. ^{[3
]}

Elballal, Mohammed S. ^{[4
]}

Abulsoud, Ahmed I. ^{[3
,5
]}

Elshaer, Shereen Saeid ^{[3
,6
]}

El-Husseiny, Ahmed A. ^{[5
,7
]}

Fathi, Doaa ^{[3
]}

Midan, Heba M.

Rizk, Nehal I. ^{[3
]}

Elrebehy, Mahmoud A.

Sayed, Ghadir A. ^{[7
]}

Tabaa, Manar Mohammed El ^{[8
]}

Salman, Aya ^{[7
]}

Mohammed, Osama A. ^{[9
]}

Ashraf, Alaa ^{[10
]}

Khidr, Emad Gamil ^{[5
]}

Khaled, Reem ^{[4
]}

El-Dakroury, Walaa A. ^{[11
]}

Helal, Gouda Kamel ^{[12
,13
]}

Moustafa, Yasser M. ^{[2
,14
]}

Doghish, Ahmed S. ^{[4
,5
]}

机构：

[1] Cairo Univ, Fac Pharm, Dept Biochem, Biochem, Cairo, Egypt

[2] Badr Univ Cairo BUC, Fac Pharm, Pharmacol & Toxicol Dept, Cairo 11829, Egypt

[3] Heliopolis Univ, Fac Pharm, Biochem Dept, Cairo 11785, Egypt

[4] Badr Univ Cairo BUC, Fac Pharm, Dept Biochem, Cairo 11829, Egypt

[5] Al Azhar Univ, Fac Pharm Boys, Biochem & Mol Biol Dept, Cairo 11231, Egypt

[6] Al Azhar Univ, Fac Pharm Girls, Dept Biochem, Cairo 11823, Egypt

[7] Egyptian Russian Univ, Fac Pharm, Dept Biochem, Cairo 11829, Egypt

[8] Univ Sadat City, Environm Studies & Res Inst ESRI, Pharmacol & Environm Toxicol, Sadat City 32897, Menoufia, Egypt

[9] Univ Bisha, Coll Med, Dept Clin Pharmacol, Bisha 61922, Saudi Arabia

[10] Badr Univ Cairo BUC, Fac Pharm, Dept Clin Pharm & Pharm Practice, Cairo 11829, Egypt

[11] Badr Univ Cairo BUC, Fac Pharm, Dept Pharmaceut & Ind Pharm, Cairo 11829, Egypt

[12] Al Azhar Univ, Fac Pharm, Dept Pharmacol & Toxicol, Cairo 11231, Egypt

[13] Heliopolis Univ, Fac Pharm, Dept Pharmacol & Toxicol, Cairo 11785, Egypt

[14] Suez Canal Univ, Fac Pharm, Dept Pharmacol & Toxicol, Ismailia 41522, Egypt

来源：

PATHOLOGY RESEARCH AND PRACTICE | 2023年 / 250卷

关键词：

MiRNA; Malignant pleural mesothelioma; MPM; Drug resistance; Diagnosis; Prognosis; EPITHELIAL-MESENCHYMAL TRANSITION; POTENTIAL VEGFR-2 INHIBITORS; CELL-CYCLE ARREST; CISPLATIN RESISTANCE; BREAST-CANCER; TUMOR-GROWTH; MDR1/P-GLYCOPROTEIN EXPRESSION; HEPATOCELLULAR-CARCINOMA; MOLECULAR-MECHANISMS; INDUCE APOPTOSIS;

D O I：

10.1016/j.prp.2023.154817

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Malignant pleural mesothelioma (MPM) is a highly lethal form of pleural cancer characterized by a scarcity of effective therapeutic interventions, resulting in unfavorable prognoses for afflicted individuals. Besides, many patients experience substantial consequences from being diagnosed in advanced stages. The available diagnostic, prognostic, and therapeutic options for MPM are restricted in scope. MicroRNAs (miRNAs) are a subset of small, noncoding RNA molecules that exert significant regulatory influence over several cellular processes within cell biology. A wide range of miRNAs have atypical expression patterns in cancer, serving specific functions as either tumor suppressors or oncomiRs. This review aims to collate, epitomize, and analyze the latest scholarly investigations on miRNAs that are believed to be implicated in the dysregulation leading to MPM. miRNAs are also discussed concerning their potential clinical usefulness as diagnostic and prognostic biomarkers for MPM. The future holds promising prospects for enhancing diagnostic, prognostic, and therapeutic modalities for MPM, with miRNAs emerging as a potential trigger for such advancements.

引用

页数：20

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