Carneusones A-F, Benzophenone Derivatives from Sponge-Derived Fungus Aspergillus carneus GXIMD00543

被引：1

作者：

Lu, Chun-Ju ^{[1
]}

Liang, Li-Fen ^{[1
]}

Zhang, Geng-Si ^{[1
]}

Li, Hai-Yan ^{[1
]}

Fu, Chun-Qing ^{[1
]}

Yu, Qin ^{[1
]}

Zhou, Dong-Mei ^{[1
]}

Su, Zhi-Wei ^{[1
]}

Liu, Kai ^{[1
]}

Gao, Cheng-Hai ^{[1
]}

Xu, Xin-Ya ^{[1
]}

Liu, Yong-Hong ^{[1
]}

机构：

[1] Guangxi Univ Chinese Med, Inst Marine Drugs, Guangxi Key Lab Marine Drugs, Nanning 530200, Peoples R China

来源：

MARINE DRUGS | 2024年 / 22卷 / 02期

关键词：

marine fungus; anti-inflammatory activity; Aspergillus carneus; benzophenone; Beibu gulf; MARINE NATURAL-PRODUCTS; METABOLITES;

D O I：

10.3390/md22020063

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Six benzophenone derivatives, carneusones A-F (1-6), along with seven known compounds (7-13) were isolated from a strain of sponge-derived marine fungus Aspergillus carneus GXIMD00543. Their chemical structures were elucidated by detailed spectroscopic data and quantum chemical calculations. Compounds 5, 6, and 8 exhibited moderate anti-inflammatory activity on NO secretion using lipopolysaccharide (LPS)-induced RAW 264.7 cells with EC50 values of 34.6 +/- 0.9, 20.2 +/- 1.8, and 26.8 +/- 1.7 mu M, while 11 showed potent effect with an EC50 value of 2.9 +/- 0.1 mu M.

引用

页数：11

共 50 条

[41] p-Terphenyl alcohols from a marine sponge-derived fungus, Aspergillus candidus OUCMDZ-1051
Dongyang Wang
Peng Qu
Jiayu Zhou
Yi Wang
Liping Wang
Weiming Zhu
Marine Life Science & Technology, 2020, 2 : 262 - 267
[42] Citrinin Derivatives and Unusual C25 Steroids from a Sponge-Derived Penicillium sp Fungus
Liu, Yun-Feng
Zhong, Rong
Cao, Fei
Wang, Cong
Wang, Chang-Yun
CHEMISTRY OF NATURAL COMPOUNDS, 2016, 52 (03) : 548 - 551
[43] Microsphaerones A and B, two novel γ-pyrone derivatives from the sponge-derived fungus Microsphaeropsis sp.
Wang, CY
Wang, BG
Brauers, G
Guan, HS
Proksch, P
Ebel, R
JOURNAL OF NATURAL PRODUCTS, 2002, 65 (05): : 772 - 775
[44] Xanthone, benzophenone and bianthrone derivatives from the hypersaline lake-derived fungus Aspergillus wentii
Form, Imke C.
Bonus, Michele
Gohlke, Holger
Lin, Wenhan
Daletos, Georgios
Proksch, Peter
BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 27 (20)
[45] New natural products from the sponge-derived fungus Aspergillus niger. (vol 67, pg 1532, 2004)
Hiort, J
Maksimenka, K
Reichert, M
Perovic-Ottstadt, S
Lin, WH
Wray, V
Steube, K
Schaumann, K
Weber, H
Proksch, P
Ebel, R
Müller, WEG
Bringmann, G
JOURNAL OF NATURAL PRODUCTS, 2005, 68 (12): : 1821 - 1821
[46] Antiviral and cytotoxic indole diterpenoids from the antarctic sponge-derived fungus Aspergillus candidus HDN15-152
Tang, Bingying
Zhang, Runfang
Zhang, Falei
Zhu, Tianjiao
Che, Qian
Li, Dehai
Zhang, Guojian
NATURAL PRODUCT RESEARCH, 2024,
[47] Phloroglucinol heterodimers and bis-indolyl alkaloids from the sponge-derived fungus Aspergillus sp. SCSIO 41018
Guo, Cui
Wang, Pei
Lin, Xiuping
Salendra, Limbadri
Kong, Fandong
Liao, Shengrong
Yang, Bin
Zhou, Xuefeng
Wang, Junfeng
Liu, Yonghong
ORGANIC CHEMISTRY FRONTIERS, 2019, 6 (17) : 3053 - 3059
[48] A new lateral root growth inhibitor from the sponge-derived fungus Aspergillus sp. LS45
Huang, Liming
Ding, Lijian
Li, Xiaohui
Wang, Ning
Yan, Yushan
Yang, Mengxiang
Cui, Wei
Naman, C. Benjamin
Cheng, Kejun
Zhang, Weiyan
Zhang, Bin
Jin, Haixiao
He, Shan
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2019, 29 (13) : 1593 - 1596
[49] Ascandinines A-D, Indole Diterpenoids, from the Sponge-Derived Fungus Aspergillus candidus HDN15-152
Zhou, Guoliang
Sun, Chunxiao
Hou, Xuewen
Che, Qian
Zhang, Guojian
Gu, Qianqun
Liu, Chenguang
Zhu, Tianjiao
Li, Dehai
JOURNAL OF ORGANIC CHEMISTRY, 2021, 86 (03): : 2431 - 2436
[50] JBIR-15, a New Aspochracin Derivative, Isolated from a Sponge-Derived Fungus, Aspergillus sclerotiorum Huber Sp080903f04
Motohashi, Keiichiro
Inaba, Shigeki
Takagi, Motoki
Shin-Ya, Kazuo
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2009, 73 (08) : 1898 - 1900

← 1 2 3 4 5 →