Carneusones A-F, Benzophenone Derivatives from Sponge-Derived Fungus Aspergillus carneus GXIMD00543

被引：1

作者：

Lu, Chun-Ju ^{[1
]}

Liang, Li-Fen ^{[1
]}

Zhang, Geng-Si ^{[1
]}

Li, Hai-Yan ^{[1
]}

Fu, Chun-Qing ^{[1
]}

Yu, Qin ^{[1
]}

Zhou, Dong-Mei ^{[1
]}

Su, Zhi-Wei ^{[1
]}

Liu, Kai ^{[1
]}

Gao, Cheng-Hai ^{[1
]}

Xu, Xin-Ya ^{[1
]}

Liu, Yong-Hong ^{[1
]}

机构：

[1] Guangxi Univ Chinese Med, Inst Marine Drugs, Guangxi Key Lab Marine Drugs, Nanning 530200, Peoples R China

来源：

MARINE DRUGS | 2024年 / 22卷 / 02期

关键词：

marine fungus; anti-inflammatory activity; Aspergillus carneus; benzophenone; Beibu gulf; MARINE NATURAL-PRODUCTS; METABOLITES;

D O I：

10.3390/md22020063

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Six benzophenone derivatives, carneusones A-F (1-6), along with seven known compounds (7-13) were isolated from a strain of sponge-derived marine fungus Aspergillus carneus GXIMD00543. Their chemical structures were elucidated by detailed spectroscopic data and quantum chemical calculations. Compounds 5, 6, and 8 exhibited moderate anti-inflammatory activity on NO secretion using lipopolysaccharide (LPS)-induced RAW 264.7 cells with EC50 values of 34.6 +/- 0.9, 20.2 +/- 1.8, and 26.8 +/- 1.7 mu M, while 11 showed potent effect with an EC50 value of 2.9 +/- 0.1 mu M.

引用

页数：11

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