The Usefulness of the Eosinophilic Esophagitis Histology Scoring System in Predicting Response to Proton Pump Inhibitor Monotherapy in Children with Eosinophilic Esophagitis

被引:2
|
作者
Jevtic, Jovan [1 ]
Ristic, Nina [2 ]
Pavlovic, Vedrana [3 ]
Svorcan, Jovana [2 ]
Milovanovich, Ivan [2 ]
Radusinovic, Milica [2 ]
Popovac, Nevena [2 ]
Simic, Ljubica [1 ]
Cirovic, Aleksandar [4 ]
Duknic, Milos [1 ]
Zivotic, Maja [1 ]
Poljasevic, Nevena [5 ]
Obradovic, Danilo [1 ]
Filipovic, Jelena [1 ]
Jankovic, Radmila [1 ]
机构
[1] Univ Belgrade, Inst Pathol, Fac Med, Belgrade 11000, Serbia
[2] Univ Childrens Hosp, Dept Gastroenterol Hepatol & GI Endoscopy, Belgrade 11000, Serbia
[3] Univ Belgrade, Inst Med Stat & Informat, Fac Med, Belgrade 11000, Serbia
[4] Univ Belgrade, Inst Anat, Fac Med, Belgrade 11000, Serbia
[5] Univ Clin Ctr Tuzla, Dept Pathol, Tuzla 75000, Bosnia & Herceg
关键词
eosinophilic esophagitis; pediatrics; EoEHSS; score; EREFS; REMISSION; EFFICACY; THERAPY;
D O I
10.3390/diagnostics13223445
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Eosinophilic esophagitis (EoE) is an immune-mediated esophageal disease with rising incidence. While proton pump inhibitors (PPIs) are the first-line treatment, a significant proportion of patients do not respond. This study aimed to determine if the EoE Histology Scoring System (EoEHSS) can predict PPI responsiveness. Methods: A cross-sectional study was conducted on 89 pediatric patients diagnosed with EoE between 2016 and 2022. Patients were categorized into PPI responders (PPIREoE) and non-responders (PPINREoE) based on post-treatment biopsies. EoEHSS values from biopsies of the esophagus (distal, middle, and proximal segments) were compared between the two groups. Results: No significant differences in EoEHSS scores were observed for the distal and proximal esophagus between the groups. However, the middle esophagus showed a significantly higher EoEHSS grade score in the PPINREoE group, indicating a more pronounced disease severity. Specific histological features, particularly eosinophilic abscesses and surface layering of the middle segment of the esophagus, were significantly different between the groups. Conclusions: Performing a biopsy of each esophageal segment, particularly the middle, is crucial for diagnostic precision and predicting PPI responsiveness. The EoEHSS can serve as a valuable tool in predicting therapy response, emphasizing the need for personalized therapeutic approaches in EoE management.
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页数:12
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