Genetic identification of human remains from the Korean War

被引：1

作者：

Zhang, Qingzhen ^{[1
]}

Liu, Liyan ^{[1
]}

Wang, Yu ^{[1
]}

Liu, Qiqi ^{[1
]}

Zhang, Minli ^{[1
]}

Zhang, Xiaochang ^{[1
]}

Tang, Zhaobing ^{[1
]}

Ding, Xiaoran ^{[1
]}

Zhang, Xiujuan ^{[1
]}

Shao, Liting ^{[1
]}

Zhou, Zhe ^{[1
]}

Wang, Shengqi ^{[1
]}

机构：

[1] Beijing Inst Radiat Med, 27 Taiping Rd, Beijing 100850, Peoples R China

来源：

ELECTROPHORESIS | 2024年 / 45卷 / 15-16期

关键词：

genetic identification; Korean War; mitochondrial DNA; short tandem repeat; SNP; SIGNATURE PREP KIT; SPANISH-CIVIL-WAR; DEVELOPMENTAL VALIDATION; INTERNATIONAL SOCIETY; ISFG RECOMMENDATIONS; SEQUENCE VARIATION; FORENSIC GENETICS; DNA COMMISSION; MASS GRAVES; PATERNITY;

D O I：

10.1002/elps.202200197

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The genetic identification of skeletal remains from Chinese People's Volunteers (CPVs) of the Korean War has been challenging because of the degraded DNA samples and the lack of living close relatives. This study established a workflow for identifying CPVs by combining Y-chromosome short tandem repeats (Y-STRs), mitochondrial DNA (mtDNA) hypervariable regions I and II, autosomal STRs (aSTRs), and identity-informative SNPs (iiSNPs). A total of 20 skeletal remains of CPVs and 46 samples from their alleged relatives were collected. The success rate of DNA extraction from human remains was 100%. Based on Y-STRs, six remains shared the same male lineages with their alleged relatives. Meanwhile, mtDNA genotyping supports two remains sharing the same maternal lineages with their alleged relatives. Likelihood ratios (LRs) were further obtained from 27 aSTRs and 94 iiSNPs or 1936 iiSNPs to confirm their relationship. All joint pedigree LRs were >100. Finally, six remains were successfully identified. This pilot study for the systematic genetic identification of CPVs from the Korean War can be applied for the large-scale identification of CPVs in the future.

引用

页码：1356 / 1369

页数：14

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