Impact of malnutrition on mortality and neurological recovery of older patients with spinal cord injury

被引：1

作者：

Tamai, Koji ^{[1
]}

Terai, Hidetomi ^{[1
]}

Nakamura, Hiroaki ^{[1
]}

Yokogawa, Noriaki ^{[2
]}

Sasagawa, Takeshi ^{[2
,3
]}

Nakashima, Hiroaki ^{[4
]}

Segi, Naoki ^{[4
]}

Ito, Sadayuki ^{[4
]}

Funayama, Toru ^{[5
]}

Eto, Fumihiko ^{[6
]}

Yamaji, Akihiro ^{[7
]}

Watanabe, Kota ^{[8
]}

Yamane, Junichi ^{[8
,9
]}

Takeda, Kazuki ^{[8
,10
]}

Furuya, Takeo ^{[11
]}

Yunde, Atsushi ^{[11
]}

Nakajima, Hideaki ^{[12
]}

Yamada, Tomohiro ^{[13
,14
]}

Hasegawa, Tomohiko ^{[13
]}

Terashima, Yoshinori ^{[15
,16
]}

Hirota, Ryosuke ^{[15
]}

Suzuki, Hidenori ^{[17
]}

Imajo, Yasuaki ^{[17
]}

Ikegami, Shota ^{[18
]}

Uehara, Masashi ^{[18
]}

Tonomura, Hitoshi ^{[19
]}

Sakata, Munehiro ^{[19
,20
]}

Hashimoto, Ko ^{[21
]}

Onoda, Yoshito ^{[21
]}

Kawaguchi, Kenichi ^{[22
]}

Haruta, Yohei ^{[22
]}

Suzuki, Nobuyuki ^{[23
]}

Kato, Kenji ^{[23
]}

Uei, Hiroshi ^{[24
,25
]}

Sawada, Hirokatsu ^{[25
]}

Nakanishi, Kazuo ^{[26
]}

Misaki, Kosuke ^{[26
]}

Kuroda, Akiyoshi ^{[27
]}

Inoue, Gen ^{[27
]}

Kakutani, Kenichiro ^{[28
]}

Kakiuchi, Yuji ^{[28
]}

Kiyasu, Katsuhito ^{[29
]}

Tominaga, Hiroyuki ^{[30
]}

Tokumoto, Hiroto ^{[30
]}

Iizuka, Yoichi ^{[31
]}

Takasawa, Eiji ^{[31
]}

Akeda, Koji ^{[32
]}

Takegami, Norihiko ^{[32
]}

Funao, Haruki ^{[33
,34
,35
,36
]}

Oshima, Yasushi ^{[37
]}

机构：

[1] Osaka Metropolitan Univ, Grad Sch Med, Dept Orthopaed Surg, 1-5-7 Asahimachi,Abenoku, Osaka, Osaka 5458585, Japan

[2] Kanazawa Univ, Grad Sch Med Sci, Dept Orthopaed Surg, 13-1 Takara Machi, Kanazawa, Ishikawa 9208641, Japan

[3] Toyama Prefectural Cent Hosp, Dept Orthopaed Surg, 2-2-78 Nishinagae, Toyama, Toyama 9308550, Japan

[4] Nagoya Univ, Grad Sch Med, Dept Orthoped Surg, 65 Tsurumai Cho,Showa Ku, Nagoya 4668550, Japan

[5] Univ Tsukuba, Fac Med, Dept Orthopaed Surg, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058575, Japan

[6] Univ Tsukuba, Grad Sch Comprehens Human Sci, Dept Orthopaed Surg, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058575, Japan

[7] Ibaraki Seinan Med Ctr Hosp, Dept Orthopaed Surg, 2190 Sakaimachi, Sashima, Ibaraki 3060433, Japan

[8] Keio Univ, Sch Med, Dept Orthopaed Surg, 35 Shinanomachi Shinjuku, Tokyo 1608582, Japan

[9] Natl Hosp Org, Murayama Med Ctr, Dept Orthopaed Surg, 2-37-1 Gakuen, Musashimurayama, Tokyo 2080011, Japan

[10] Japanese Red Cross Shizuoka Hosp, Dept Orthopaed Surg, 8-2 Ohtemachi,Aoi Ku, Shizuoka 4200853, Japan

[11] Chiba Univ, Grad Sch Med, Dept Orthopaed Surg, 1-8-1 Inohana,Chuo Ku, Chiba, Chiba 2608670, Japan

[12] Univ Fukui, Dept Orthopaed & Rehabil Med, Fac Med Sci, 23-3 Matsuoka Shimoaizuki,Eiheiji Cho, Fukui 9101193, Japan

[13] Hamamatsu Univ, Sch Med, Dept Orthopaed Surg, 1-20-1 Handayama,Higashi Ku, Hamamatsu, Shizuoka 4313192, Japan

[14] Nagoya Kyoritsu Hosp, Dept Orthopaed Surg, 1-172 Hokke,Nakagawa Ku, Nagoya, Aichi 4540933, Japan

[15] Sapporo Med Univ, Dept Orthopaed Surg, South 1 West 16-291,Chuo Ku, Sapporo, Hokkaido 0608543, Japan

[16] Matsuda Orthoped Mem Hosp, Dept Orthopaed Surg, North 18 East 4-1 Kita Ku, Sapporo 0010018, Japan

[17] Yamaguchi Univ, Grad Sch Med, Dept Orthopaed Surg, 1-1-1 Minami Kogushi, Ube, Yamaguchi 7558505, Japan

[18] Shinshu Univ, Sch Med, Dept Orthopaed Surg, 3-1-1 Asahi, Matsumoto, Nagano 3908621, Japan

[19] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Orthopaed, Kawaramachi Hirokoji,Kamigyo Ku, Kyoto 6028566, Japan

[20] Saiseikai Shiga Hosp, Dept Orthopaed, 2-4-1 Ohashi, Ritto, Shiga 5203046, Japan

[21] Tohoku Univ, Dept Orthopaed Surg, Grad Sch Med, 1-1 Seiryo Machi,Aoba Ku, Sendai, Miyagi 9808574, Japan

[22] Kyushu Univ, Grad Sch Med Sci, Dept Orthopaed Surg, 3-1-1 Maidashi,Higashi Ku, Fukuoka 8128582, Japan

[23] Nagoya City Univ, Dept Orthopaed Surg, Grad Sch Med Sci, 1 Kawasumi,Mizuho Cho,Mizuho Ku, Nagoya, Aichi 4678601, Japan

[24] Nihon Univ Hosp, Dept Orthopaed Surg, 1-6 Kanda Surugadai,Chiyoda Ku, Tokyo 1018393, Japan

[25] Nihon Univ, Dept Orthopaed Surg, Sch Med, 30-1 Oyaguchi Kami Cho,Itabashi Ku, Tokyo 1738610, Japan

[26] Kawasaki Med Sch, Dept Orthoped Surg, 577 Matsushima, Kurashiki, Okayama 7010192, Japan

[27] Kitasato Univ, Sch Med, Dept Orthoped Surg, 1-15-1 Kitazato,Minami Ku, Sagamihara, Kanagawa 2520374, Japan

[28] Kobe Univ, Dept Orthopaed Surg, Grad Sch Med, 7-5-1 Kusunoki Cho,Chuo Ku, Kobe 6500017, Japan

[29] Kochi Univ, Kochi Med Sch, Dept Orthopaed Surg, Oko Cho, Nankoku 7838505, Japan

[30] Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Orthopaed Surg, 8-35-1 Sakuragaoka, Kagoshima 8908520, Japan

[31] Gunma Univ, Grad Sch Med, Dept Orthopaed Surg, 3-39-22 Showa, Maebashi, Gunma 3718511, Japan

[32] Mie Univ, Grad Sch Med, Dept Orthopaed Surg, 2-174 Edobashi, Tsu, Mie 5148507, Japan

[33] Int Univ Hlth & Welf, Sch Med, Dept Orthopaed Surg, 852 Hatakeda, Narita, Chiba 2860124, Japan

[34] Int Univ Hlth, Welf Narita Hosp, Dept Orthopaed Surg, 852 Hatakeda, Narita, Chiba 2860124, Japan

[35] Int Univ Hlth, Welf Mita Hosp, Dept Orthopaed Surg, 1-4-3 Mita,Minato Ku, Tokyo 1088329, Japan

[36] Int Univ Hlth, Welf Mita Hosp, Spine & Spinal Cord Ctr, 1-4-3 Mita,Minato Ku, Tokyo 1088329, Japan

[37] Univ Tokyo Hosp, Dept Orthopaed Surg, 7-3-1 Hongo,Bunkyo Ku, Tokyo 1138655, Japan

[38] Osaka Univ, Grad Sch Med, Dept Orthopaed Surg, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan

[39] Tokai Univ, Sch Med, Dept Orthoped Surg Surg Sci, 143 Shimokasuya, Isehara, Kanagawa 2591193, Japan

[40] Tokyo Med & Dent Univ, Dept Orthopaed Surg, 1-5-45 Yushima,Bunkyo Ku, Tokyo 1138519, Japan

[41] Univ Yamanashi, Dept Orthopaed Surg, 1110 Shimokato, Chuo, Yamanashi 4093898, Japan

[42] Kyoto Univ, Grad Sch Med, Dept Orthopaed Surg, 54 Shogoin Kawaracho,Sakyo Ku, Kyoto, Kyoto, Japan

[43] Univ Toyama, Fac Med, Dept Orthopaed Surg, 2630 Sugitani, Toyama, Toyama 9300194, Japan

[44] Oita Univ, Fac Med, Dept Orthopaed Surg, 1-1 Idaigaoka,Hasama Machi, Yufu, Oita 8795593, Japan

[45] Kansai Med Univ Hosp, Dept Orthopaed Surg, 2-3-1 Shinmachi, Hirakata, Osaka 5731191, Japan

来源：

SCIENTIFIC REPORTS | 2024年 / 14卷 / 01期

关键词：

NUTRITIONAL RISK INDEX;

D O I：

10.1038/s41598-024-56527-y

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

This retrospective cohort study established malnutrition's impact on mortality and neurological recovery of older patients with cervical spinal cord injury (SCI). It included patients aged >= 65 years with traumatic cervical SCI treated conservatively or surgically. The Geriatric Nutritional Risk Index was calculated to assess nutritional-related risk. Overall, 789 patients (mean follow-up: 20.1 months) were examined and 47 had major nutritional-related risks on admission. One-year mortality rate, median survival time, neurological recovery, and activities of daily living (ADL) at 1 year post-injury were compared between patients with major nutrition-related risk and matched controls selected using 1:2 propensity score matching to adjust for age, pre-traumatic neurological impairment, and activity. In the Kaplan-Meier analysis, the median survival times were 44.9 and 76.5 months for patients with major nutrition-related risk and matched controls, respectively (p = 0.015). Matched controls had more individuals with a neurological improvement of American Spinal Injury Association Impairment Scale >= 1 grade (p = 0.039) and independence in ADL at 1 year post-injury than patients with major nutrition-related risk (p < 0.05). In conclusion, 6% of older patients with cervical SCI had major nutrition-related risks; they showed a significantly higher 1 year mortality rate, shorter survival time, poorer neurological improvement, and lower ADL at 1 year post-injury than matched controls.

引用

页数：9

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