Cancer-associated fibroblasts in hematologic malignancies: elucidating roles and spotlighting therapeutic targets

被引:6
|
作者
Ding, Ziyang [1 ]
Shi, Run [2 ]
Hu, Weikang [3 ]
Tian, Lei [3 ]
Sun, Rong [4 ]
Wu, Yang [3 ]
Zhang, Xiaoyan [5 ]
机构
[1] Nanjing Med Univ, Clin Sch 2, Nanjing, Peoples R China
[2] Nanjing Med Univ, Dept Oncol, Affiliated Hosp 1, Nanjing, Peoples R China
[3] Nanjing Med Univ, Pancreas Ctr, Affiliated Hosp 1, Nanjing, Peoples R China
[4] Jinling Hosp, Dept Radiat Oncol, Nanjing, Peoples R China
[5] Shanghai Jiao Tong Univ, Tongren Hosp, Dept Hematol, Sch Med, Shanghai, Peoples R China
来源
FRONTIERS IN ONCOLOGY | 2023年 / 13卷
关键词
cancer associated fibroblast (CAF); hematologic malignancies; crosstalk; chemoresistance; therapeutic target; LYMPHOCYTIC-LEUKEMIA CELLS; MESENCHYMAL STROMAL CELLS; TUMOR MICROENVIRONMENT; INHIBITION; TRANSITION; EXPRESSION; INDUCE;
D O I
10.3389/fonc.2023.1193978
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Hematologic malignancies comprise a diverse range of blood, bone marrow, and organ-related disorders that present significant challenges due to drug resistance, relapse, and treatment failure. Cancer-associated fibroblasts (CAFs) represent a critical component of the tumor microenvironment (TME) and have recently emerged as potential therapeutic targets. In this comprehensive review, we summarize the latest findings on the roles of CAFs in various hematologic malignancies, including acute leukemia, multiple myeloma, chronic lymphocytic leukemia, myeloproliferative neoplasms, and lymphoma. We also explore their involvement in tumor progression, drug resistance, and the various signaling pathways implicated in their activation and function. While the underlying mechanisms and the existence of multiple CAF subtypes pose challenges, targeting CAFs and their associated pathways offers a promising avenue for the development of innovative treatments to improve patient outcomes in hematologic malignancies.
引用
收藏
页数:7
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