Nanosphere and Microsphere-Based Drug Delivery Systems for Wound Healing Applications: A Review

Chronic and acute wounds pose a huge burden on patients and health care systems. Early diagnosis and prompt treatment is essential in preventing further complications such as limb amputation and infection. Recent progress in our understanding of different wounds' pathophysiology, has resulted in developing different drug delivery vehicles to target different phases of wound healing. During the past decade, microspheres and nanospheres have gained significant attention in drug delivering wound dressings. These vehicles have gained popularity largely due their biocompatibility, biodegradability, their high capacity to deliver various drug types, and long term sustained release profile. In the current review, we will discuss the challenges and prospects of microsphere and nanosphere-based drug delivery systems in wound healing.