Metabolic regulation of dendritic cell activation and immune function during inflammation

被引：10

作者：

Wu, Lili ^{[1
,2
,3
]}

Yan, Ziqi ^{[1
,2
,3
]}

Jiang, Yiyang ^{[1
,2
,3
]}

Chen, Yingyi ^{[1
,2
,3
]}

Du, Juan ^{[1
,2
,3
]}

Guo, Lijia ^{[4
]}

Xu, Junji ^{[1
,2
,3
]}

Luo, Zhenhua ^{[1
,2
,3
]}

Liu, Yi ^{[1
,2
,3
]}

机构：

[1] Capital Med Univ, Lab Tissue Regenerat & Immunol, Beijing, Peoples R China

[2] CapitalMed Univ, Sch Stomatol, Dept Periodont, Beijing Key Lab Tooth Regenerat & Funct Reconstruc, Beijing, Peoples R China

[3] Capital Med Univ, Beijing Friendship Hosp, Immunol Res Ctr Oral & Syst Hlth, Beijing, Peoples R China

[4] Capital Med Univ, Dept Orthodont, Sch Stomatol, Beijing, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷

关键词：

metabolic reprogramming; glycolysis; inflammation; dendritic cells (DC); cellular metabolism; LOW-GRADE INFLAMMATION; CHAIN AMINO-ACIDS; SCAVENGER RECEPTOR; GLYCOLYTIC METABOLISM; MECHANISTIC TARGET; CUTTING EDGE; NITRIC-OXIDE; MOUSE; MACROPHAGES; GENERATION;

D O I：

10.3389/fimmu.2023.1140749

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Dendritic cells (DCs) are antigen-presenting cells that bridge innate and adaptive immune responses. Multiple cell types, including DCs, rely on cellular metabolism to determine their fate. DCs substantially alter cellular metabolic pathways during activation, such as oxidative phosphorylation, glycolysis, fatty acid and amino acid metabolism, which have crucial implications for their functionality. In this review, we summarize and discuss recent progress in DC metabolic studies, focusing on how metabolic reprogramming influences DC activation and functionality and the potential metabolic differences among DC subsets. Improving the understanding of the relationship between DC biology and metabolic regulation may provide promising therapeutic targets for immune-mediated inflammatory diseases.

引用

页数：12

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