Metabolic Regulation of Dendritic Cell Differentiation

被引:40
|
作者
He, Zhimin [1 ,2 ]
Zhu, Xinyi [1 ]
Shi, Zhen [1 ]
Wu, Tao [1 ]
Wu, Li [1 ,2 ]
机构
[1] Tsinghua Univ, Inst Immunol, Sch Med, Beijing, Peoples R China
[2] Tsinghua Peking Ctr Life Sci, Beijing, Peoples R China
来源
FRONTIERS IN IMMUNOLOGY | 2019年 / 10卷
基金
中国国家自然科学基金;
关键词
dendritic cell (DC); cell differentiation; metabolic regulation; glycolysis; fatty acid (FA); mitochondria function; mTOR pathway; nutrients; BONE-MARROW PROGENITORS; IN-VITRO; MAMMALIAN TARGET; RETINOIC ACID; CUTTING EDGE; T-CELLS; MATURATION; RAPAMYCIN; GENERATION; MOUSE;
D O I
10.3389/fimmu.2019.00410
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Dendritic cells (DCs) are important antigen-presenting cells (APCs) that play essential roles in bridging innate and adaptive immune responses. Differentiation stages of DC subsets from bone marrow progenitor cells have been well-defined during the past decades. Features that distinguish DC progenitor cells from each differentiation stages, related signaling pathways and transcription factors that are crucial for DC lineage commitment have been well-elucidated in numerous studies. Recently, growing evidence are showing that cellular metabolism, as one of the most fundamental process of cells, has essential role in the modulation of immune system. There have been multiple reports and reviews that focus on the metabolic modulations on DC functions, however little attention had been paid to the metabolic regulation of DC development and differentiation. In recent years, increasing evidence suggests that metabolic regulations also exert significant impact on DC differentiation, as well as on the homeostasis of tissue resident DCs. The focus of this review is to summarize the findings from recent studies on the metabolic regulation of DC differentiation and to discuss the impacts of the three major aspects of metabolism on the processes of DC development and differentiation, namely the changes in metabolic pathways, the molecular signaling pathways that modulate cell metabolism, and the effects of metabolites and nutrients. The aim of this review is to draw attentions to this important and exciting research field where the effects of metabolic process and their regulation in DC differentiation need to be further explored.
引用
收藏
页数:10
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