Chemoselective three-component synthesis of α-carbolines under metal-free conditions

被引：5
|
作者：
Feng, Wei [1 ]
Zhang, Chao [1 ]
Zhou, Xinlin [1 ]
You, Kuiyi [2 ]
Deng, Guo-Jun [1 ,3 ]
Chen, Shanping [1 ]
机构：
[1] Xiangtan Univ, Key Lab Green Organ Synth & Applicat Hunan Prov, Key Lab Environm Friendly Chem & Applicat, Minist Educ,Coll Chem, Xiangtan 411105, Peoples R China
[2] Xiangtan Univ, Sch Chem Engn, Xiangtan 411105, Peoples R China
[3] Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Henan, Peoples R China
来源：
ORGANIC CHEMISTRY FRONTIERS | 2023年 / 10卷 / 21期
基金：
中国国家自然科学基金;
关键词：
MULTICOMPONENT REACTIONS; BETA; DERIVATIVES; ACID; MESCENGRICIN; PYRIDINES; ANALOGS; POTENT; AGENTS;
D O I：
10.1039/d3qo01274c
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An I2O5-promoted three-component tandem reaction for the rapid construction of alpha-carbolines has been described. The present approach starts from easily available starting materials, chemoselectively producing various alpha-carbolines in satisfactory yields under simple and metal-free conditions. Most importantly, this strategy can provide anticancer active molecules in one step on the gram scale. An I2O5-promoted chemoselective three-component tandem reaction of indole-3-carboxaldehydes, ammonium acetate, and alkynes for the construction of alpha-carbolines under metal-free conditions has been described.
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页码：5457 / 5462
页数：6
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