Biomarkers for dementia in Latin American countries: Gaps and opportunities

被引：21

作者：

Parra, Mario A. ^{[1
]}

Orellana, Paulina ^{[2
,3
]}

Leon, Tomas ^{[4
,5
,6
]}

Victoria, Cabello G. ^{[2
,7
,8
,9
]}

Henriquez, Fernando ^{[7
,8
,10
,11
]}

Gomez, Rodrigo ^{[5
,6
,12
]}

Avalos, Constanza ^{[2
,3
]}

Damian, Andres ^{[13
]}

Slachevsky, Andrea ^{[5
,6
,7
,8
,10
,14
]}

Ibanez, Agustin ^{[2
,3
,4
,15
,16
,17
,18
,19
]}

Zetterberg, Henrik ^{[20
,21
,22
,23
,24
]}

Tijms, Betty M. ^{[25
]}

Yokoyama, Jennifer S. ^{[15
,16
,17
,26
]}

Pina-Escudero, Stefanie D. ^{[27
]}

Cochran, J. Nicholas ^{[28
]}

Matallana, Diana L. ^{[29
,30
,31
,32
]}

Acosta, Daisy ^{[33
]}

Allegri, Ricardo ^{[34
,35
]}

Arias-Suarez, Bianca P. ^{[36
]}

Barra, Bernardo ^{[37
,38
]}

Behrens, Maria Isabel ^{[14
,39
,40
,41
,42
]}

Brucki, SoniaM. D. ^{[43
]}

Busatto, Geraldo ^{[44
]}

Caramelli, Paulo ^{[45
]}

Castro-Suarez, Sheila ^{[27
,46
]}

Contreras, Valeria ^{[47
]}

Custodio, Nilton ^{[48
]}

Dansilio, Sergio ^{[49
]}

De la Cruz-Puebla, Myriam ^{[15
,16
,17
,50
,51
,52
]}

de Souza, Leonardo Cruz ^{[44
,53
]}

Diaz, Monica M. ^{[54
,55
]}

Duque, Lissette ^{[56
]}

Farias, Gonzalo A. ^{[39
,40
]}

Ferreira, Sergio T. ^{[57
]}

Guimet, Nahuel Magrath ^{[27
,34
]}

Kmaid, Ana ^{[58
]}

Lira, David ^{[48
]}

Lopera, Francisco ^{[59
]}

Meza, Beatriz Mar ^{[27
,60
]}

Miotto, Eliane C. ^{[43
]}

Nitrini, Ricardo ^{[43
]}

Nunez, Alberto ^{[56
]}

O'Neill, Santiago ^{[61
]}

Ochoa, John ^{[62
]}

Pintado-Caipa, Maritza ^{[27
,48
]}

Resende, Elisa de Paula Franca ^{[15
,16
,17
,45
,53
,63
,64
]}

Risacher, Shannon ^{[65
]}

Rojas, Luz Angela ^{[66
]}

Sabaj, Valentina ^{[67
]}

Schilling, Lucas ^{[53
,63
,68
]}

机构：

[1] Univ Strathclyde, Sch Psychol Sci & Hlth, Glasgow, Lanark, Scotland

[2] Univ Adolfo Ibanez, Latin Amer Inst Brain Hlth BrainLat, Santiago, Chile

[3] Univ Adolfo Ibanez, Sch Psychol, Ctr Social & Cognit Neurosci CSCN, Santiago, Chile

[4] Trinity Coll Dublin, Global Brain Hlth Inst, Dublin, Ireland

[5] Univ Chile, Hosp Salvador, Memory & Neuropsychiat Clin CMYN Neurol Dept, Santiago, Chile

[6] Univ Chile, Fac Med, Santiago, Chile

[7] Univ Chile, Physiopathol Dept, Inst Biomed Sci ICBM,Fac Med, Neuropsychol & Clin Neurosci Lab LANNEC,Neurosci, Santiago, Chile

[8] Univ Chile, Physiopathol Dept, Inst Biomed Sci ICBM,Fac Med, Neuropsychol & Clin Neurosci Lab LANNEC,East Neur, Santiago, Chile

[9] Univ Chile, Dept Neurol & Neurosurg, Unit Brain Hlth, Fac Med, Santiago, Chile

[10] Gerosci Ctr Brain Hlth & Metab GERO, Santiago, Chile

[11] Pontificia Univ Catolica Chile, Dept Psychiat, Lab Cognit & Evolutionary Neurosci LaNCE, Fac Med, Santiago, Chile

[12] Univ Mayor, Chile Ctr Apoyo Comunitario Personas Demencia Kin, Grad Sch, Fac Med, Santiago, Chile

[13] Univ Republica, Ctr Uruguayo Imagenol Mol CUDIM, Hosp Clin, Ctr Med Nucl & Imagenol Mol, Montevideo, Uruguay

[14] Clin Alemana Univ Desarrollo, Dept Neurol & Psyquiatry, Santiago, Chile

[15] Univ Calif San Francisco UCSF, Global Brain Hlth Inst, San Francisco, CA USA

[16] Univ Calif San Francisco UCSF, Mem & Aging Ctr, Weill Inst Neurosci, Dept Neurol, San Francisco, CA USA

[17] Univ Calif San Francisco UCSF, Mem & Aging Ctr, Weill Inst Neurosci, Dept Radiol & Biomed Imaging, San Francisco, CA USA

[18] Univ San Andres, Cognit Neurosci Ctr CNC, Buenos Aires, DF, Argentina

[19] Natl Sci & Tech Res Council CONICET, Buenos Aires, DF, Argentina

[20] Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Molndal, Sweden

[21] Sahlgrens Univ Hosp, Clin Neurochem Lab, Molndal, Sweden

[22] UCL Inst Neurol, Dept Neurodegenerat Dis, Queen Sq, London, England

[23] UCL, UK Dementia Res Inst, London, England

[24] Hong Kong Ctr Neurodegenerat Dis, Clear Water Bay, Hong Kong, Peoples R China

[25] Amsterdam UMC, Dept Neurol, Alzheimer Ctr Amsterdam, Amsterdam Neurosci, Amsterdam, Netherlands

[26] UCSF, Memory & Aging Ctr, Dept Neurol, San Francisco, CA USA

[27] Univ Calif San Francisco, Global Brain Hlth Inst GBHI, Equ Brain Hlth, San Francisco, CA 94143 USA

[28] HudsonAlpha Inst Biotechnol, Huntsville, AL USA

[29] Pontificia Univ Javeriana, Aging Inst, Med Sch, Bogota, Colombia

[30] Pontificia Univ Javeriana, Psychiat Dept, Neurosci PhD Program, Bogota, Colombia

[31] Hosp Univ San Ignacio, Memory & Cognit Ctr, Intellectus, Bogota, Colombia

[32] Hosp Univ Santa Fe Bogota, Dept Psychiat, Bogota, Colombia

[33] Univ Nacl Pedro Henriquez Urena UNPHU, Santo Domingo, Dominican Rep

[34] Inst Neurol Fleni, Dept Cognit Neurol Neuropsychiat & Neuropsychol, Buenos Aires, DF, Argentina

[35] Univ Costa, Dept Neurosci, Barranquilla, Colombia

[36] Natl Univ San Marcos, Postgrad Sect, Fac Human Med, Lima, Peru

[37] Clin Univ Andes, Mental Hlth Serv, Santiago, Chile

[38] Andres Bello Univ Santiago UNAB, Med Sch, Dept Psychiat, Santiago, Chile

[39] Univ Chile, Dept Neurol & Neurosurg, Ctr Adv Clin Res CICA, Santiago, Chile

[40] Univ Chile, Neurosci Dept, Fac Med, Santiago, Chile

[41] Hosp Clin Univ Chile, Dept Neurol & Neurosurg, Santiago, Chile

[42] Univ Chile, Dept Neurosci, Fac Med, Santiago, Chile

[43] Univ Sao Paulo, Univ Sao Paulo Med Sch, Dept Neurol, Cognit & Behav Neurol Unit, Sao Paulo, Brazil

[44] Univ Sao Paulo HCFMUSP, Dept Inst Psiquiatria, Hosp Clin, Fac Med, Sao Paulo, Brazil

[45] Univ Fed Minas Gerais, Behav & Cognit Neurol Unit, Fac Med, Belo Horizonte, MG, Brazil

[46] Inst Nacl Ciencias Neurol, Lima, Peru

[47] Hosp Cent Fuerzas Armadas, Montevideo, Uruguay

[48] Inst Peruano Neurociencias, Unit Diag Cognit Impairment & Dementia Prevent, Lima, Peru

[49] Univ Republica, Inst Neurol, Hosp Clin, Dept Neuropsychol,Fac Med, Montevideo, Uruguay

[50] Bellvitge Biomed Res Inst, Cognit & Brain Plast Unit, Barcelona, Spain

来源：

ALZHEIMERS & DEMENTIA | 2023年 / 19卷 / 02期

基金：

瑞典研究理事会; 美国国家卫生研究院; 欧洲研究理事会;

关键词：

BLOOD-BASED BIOMARKERS; ALZHEIMERS-DISEASE; CANDIDATE GENE; TAU; DIAGNOSIS; ASSOCIATION; TOMOGRAPHY; PREVALENCE; BURDEN; RISK;

D O I：

10.1002/alz.12757

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Limited knowledge on dementia biomarkers in Latin American and Caribbean (LAC) countries remains a serious barrier. Here, we reported a survey to explore the ongoing work, needs, interests, potential barriers, and opportunities for future studies related to biomarkers. The results show that neuroimaging is the most used biomarker (73%), followed by genetic studies (40%), peripheral fluids biomarkers (31%), and cerebrospinal fluid biomarkers (29%). Regarding barriers in LAC, lack of funding appears to undermine the implementation of biomarkers in clinical or research settings, followed by insufficient infrastructure and training. The survey revealed that despite the above barriers, the region holds a great potential to advance dementia biomarkers research. Considering the unique contributions that LAC could make to this growing field, we highlight the urgent need to expand biomarker research. These insights allowed us to propose an action plan that addresses the recommendations for a biomarker framework recently proposed by regional experts.

引用

页码：721 / 735

页数：15

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