Emerging Mutual Regulatory Roles between m6A Modification and microRNAs

N-6-metyladenosine (m(6)A), one of the most common RNA methylation modifications in mammals, has attracted extensive attentions owing to its regulatory roles in a variety of physiological and pathological processes. As a reversible epigenetic modification on RNAs, m(6)A is dynamically mediated by the functional interplay among the regulatory proteins of methyltransferases, demethylases and methyl-binding proteins. In recent years, it has become increasingly clear that m(6)A modification is associated with the production and function of microRNAs (miRNAs). In this review, we summarize the specific kinds of m(6)A modification methyltransferases, demethylases and methyl-binding proteins. In particular, we focus on describing the roles of m(6)A modification and its regulatory proteins in the production and function of miRNAs in a variety of pathological and physiological processes. More importantly, we further discuss the mediating mechanisms of miRNAs in m(6)A modification and its regulatory proteins during the occurrence and development of various diseases.