Stem cell-based therapy for COVID-19

被引：3
|
作者：
Chen, Xiaomei [1 ]
Liu, Bowen [1 ]
Li, Chao [1 ]
Wang, Yulian [1 ]
Geng, Suxia [1 ]
Du, Xin [1 ]
Weng, Jianyu [1 ]
Lai, Peilong [1 ]
机构：
[1] Southern Med Univ, Guangdong Prov People Hosp, Guangdong Acad Med Sci, Dept Hematol, Guangzhou 510080, Guangdong, Peoples R China
来源：
INTERNATIONAL IMMUNOPHARMACOLOGY | 2023年 / 124卷
基金：
中国国家自然科学基金;
关键词：
COVID-19; Mesenchymal stem cells; Extracellular vesicle; Cell -based therapy; Clinical trials; Vaccines; MESENCHYMAL STROMAL CELLS; RESPIRATORY-DISTRESS-SYNDROME; VERSUS-HOST-DISEASE; ACUTE LUNG INJURY; SPHEROID CULTURE; SARS-COV-2; TRANSPLANTATION; IMMUNITY; SURVIVAL; MSCS;
D O I：
10.1016/j.intimp.2023.110890
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
While The World Health Organization (WHO) has announced that COVID-19 is no longer a public health emergency of international concern(PHEIC), the risk of reinfection and new emerging variants still makes it crucial to study and work towards the prevention of COVID-19. Stem cell and stem cell-like derivatives have shown some promising results in clinical trials and preclinical studies as an alternative treatment option for the pulmonary illnesses caused by the COVID-19 and can be used as a potential vaccine. In this review, we will systematically summarize the pathophysiological process and potential mechanisms underlying stem cell-based therapy in COVID-19, and the registered COVID-19 clinical trials, and engineered extracellular vesicle as a potential vaccine for preventing COVID-19.
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页数：11
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