Stem cell-based therapy for COVID-19

被引：3

作者：

Chen, Xiaomei ^{[1
]}

Liu, Bowen ^{[1
]}

Li, Chao ^{[1
]}

Wang, Yulian ^{[1
]}

Geng, Suxia ^{[1
]}

Du, Xin ^{[1
]}

Weng, Jianyu ^{[1
]}

Lai, Peilong ^{[1
]}

机构：

[1] Southern Med Univ, Guangdong Prov People Hosp, Guangdong Acad Med Sci, Dept Hematol, Guangzhou 510080, Guangdong, Peoples R China

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2023年 / 124卷

基金：

中国国家自然科学基金;

关键词：

COVID-19; Mesenchymal stem cells; Extracellular vesicle; Cell -based therapy; Clinical trials; Vaccines; MESENCHYMAL STROMAL CELLS; RESPIRATORY-DISTRESS-SYNDROME; VERSUS-HOST-DISEASE; ACUTE LUNG INJURY; SPHEROID CULTURE; SARS-COV-2; TRANSPLANTATION; IMMUNITY; SURVIVAL; MSCS;

D O I：

10.1016/j.intimp.2023.110890

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

While The World Health Organization (WHO) has announced that COVID-19 is no longer a public health emergency of international concern(PHEIC), the risk of reinfection and new emerging variants still makes it crucial to study and work towards the prevention of COVID-19. Stem cell and stem cell-like derivatives have shown some promising results in clinical trials and preclinical studies as an alternative treatment option for the pulmonary illnesses caused by the COVID-19 and can be used as a potential vaccine. In this review, we will systematically summarize the pathophysiological process and potential mechanisms underlying stem cell-based therapy in COVID-19, and the registered COVID-19 clinical trials, and engineered extracellular vesicle as a potential vaccine for preventing COVID-19.

引用

页数：11

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