Overcoming barriers: a review on innovations in drug delivery to the middle and inner ear

被引:7
|
作者
Delaney, Derek S. [1 ,2 ]
Liew, Lawrence J. [1 ,3 ]
Lye, Joey [1 ]
Atlas, Marcus D. [1 ,3 ,4 ]
Wong, Elaine Y. M. [1 ,3 ,4 ]
机构
[1] Ear Sci Inst Australia, Hearing Therapeut, Nedlands, WA, Australia
[2] Curtin Univ, Fac Hlth Sci, Curtin Hlth Innovat Res Inst, Bentley, WA, Australia
[3] Univ Western Australia, Ctr Ear Sci, Med Sch, Nedlands, WA, Australia
[4] Curtin Univ, Fac Hlth Sci, Curtin Med Sch, Bentley, WA, Australia
基金
英国医学研究理事会;
关键词
drug delivery; inner ear; middle ear; hydrogel; nanoparticle; biomaterials; microdevices; SENSORINEURAL HEARING-LOSS; PLATELET-RICH PLASMA; TYMPANIC MEMBRANE PERFORATIONS; SOLID LIPID NANOPARTICLES; FIBROBLAST-GROWTH-FACTOR; CHRONIC OTITIS-MEDIA; IN-VIVO DELIVERY; COCHLEAR IMPLANTATION; HAIR-CELLS; CONGENITAL CHOLESTEATOMA;
D O I
10.3389/fphar.2023.1207141
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Despite significant advances in the development of therapeutics for hearing loss, drug delivery to the middle and inner ear remains a challenge. As conventional oral or intravascular administration are ineffective due to poor bioavailability and impermeability of the blood-labyrinth-barrier, localized delivery is becoming a preferable approach for certain drugs. Even then, localized delivery to the ear precludes continual drug delivery due to the invasive and potentially traumatic procedures required to access the middle and inner ear. To address this, the preclinical development of controlled release therapeutics and drug delivery devices have greatly advanced, with some now showing promise clinically. This review will discuss the existing challenges in drug development for treating the most prevalent and damaging hearing disorders, in particular otitis media, perforation of the tympanic membrane, cholesteatoma and sensorineural hearing loss. We will then address novel developments in drug delivery that address these including novel controlled release therapeutics such as hydrogel and nanotechnology and finally, novel device delivery approaches such as microfluidic systems and cochlear prosthesis-mediated delivery. The aim of this review is to investigate how drugs can reach the middle and inner ear more efficiently and how recent innovations could be applied in aiding drug delivery in certain pathologic contexts.
引用
收藏
页数:19
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