Characteristics, prognostic determinants of monocytes, macrophages and T cells in acute coronary syndrome: protocol for a multicenter, prospective cohort study

被引:2
|
作者
Lin, Muzhi [1 ]
Wang, Bing [2 ]
Wei, Bo [1 ]
Li, Chao [2 ]
Tu, Lin [3 ]
Zhu, Xiaohan [4 ]
Wu, Zheyi [2 ]
Huang, Guangwei [2 ]
Lu, Xiyang [2 ]
Xiong, Guobao [1 ]
Lu, Shanglin [1 ]
Yang, Xinglin [5 ]
Li, Peng [6 ]
Liu, Xingde [7 ]
Li, Wei [1 ]
Lu, Yuming [3 ]
Zhou, Haiyan [1 ]
机构
[1] Guizhou Med Univ, Affiliated Hosp, Dept Cardiol Vasc Med, Guiyang 550000, Guizhou, Peoples R China
[2] Guizhou Med Univ, Dept Internal Med, Guiyang, Guizhou, Peoples R China
[3] First Peoples Hosp Guiyang, Internal Med Cardiovasc Dept, Guiyang 550000, Guizhou, Peoples R China
[4] Second Peoples Hosp Guiyang, Dept Cardiol, Guiyang, Guizhou, Peoples R China
[5] Guiyang Publ Hlth Clin Ctr, Dept Clin Lab, Guiyang, Guizhou, Peoples R China
[6] Guiyang Publ Hlth Clin Ctr, Sci & Educ Div, Guiyang, Guizhou, Peoples R China
[7] Guizhou Univ Tradit Chinese Med, Affiliated Hosp 2, Dept Cardiovasc Med, Guiyang, Guizhou, Peoples R China
基金
中国国家自然科学基金;
关键词
Characteristics; Prognosis; Monocytes; Macrophages; T cells; Acute coronary syndrome; MACE; MYOCARDIAL-INFARCTION; BLOOD MONOCYTES; INFLAMMATION; CD47;
D O I
10.1186/s12872-023-03224-9
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
BackgroundAcute coronary syndrome(ACS) is the leading cause of mortality and disability worldwide. Immune response has been confirmed to play a vital role in the occurrence and development of ACS. The objective of this prospective, multicenter, observational study is to define immune response and their relationship to the occurrence and progressive of ACS.MethodsThis is a multicenter, prospective, observational longitudinal cohort study. The primary outcome is the incidence of major adverse cardiovascular events (MACE) including in-stent restenosis, severe ventricular arrhythmia, heart failure, recurrent angina pectoris, and sudden cardiac death, and stroke one year later after ACS. Demographic characteristics, clinical data, treatments, and outcomes are collected by local investigators. Furthermore, freshly processed samples will be stained and assessed by flow cytometry. The expression of S100A4, CD47, SIRP alpha and Tim-3 on monocytes, macrophages and T cells in ACS patients were collected. Follow-up: during hospitalization, 3, 6 and 12 months after discharge.DiscussionIt is expected that this study will reveal the possible targets to improve the prognosis or prevent from occurrence of MACE in ACS patients. Since it's a multicenter study, the enrollment rate of participants will be accelerated and it can ensure that the collected data are more symbolic and improve the richness and credibility of the test basis.Ethics and disseminationThis study has been registered in Chinese Clinical Trial Registry Center. Ethical approval was obtained from the Affiliated Hospital of Guizhou Medical University. The dissemination will occur through the publication of articles in international peer-reviewed journals.
引用
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页数:9
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