Crosstalk Between Autophagy and Inflammation in Chronic Cerebral Ischaemia

被引：6
|
作者：
Zhou, Hai-qian [1 ,3 ]
Zhang, Li-mei [1 ,2 ,3 ]
Li, Xiao [1 ,2 ,3 ]
Huang, Zhi-hua [1 ,2 ,3 ]
机构：
[1] Gannan Med Univ, Key Lab Prevent & Treatment Cardiovasc & Cerebrova, Minist Educ, 1st Hexie Rd, Ganzhou 341000, Peoples R China
[2] Gannan Med Univ, Sch Basic Med Sci, Dept Physiol, 1st Hexie Rd, Ganzhou 341000, Peoples R China
[3] Gannan Med Univ, Ganzhou Key Lab Neuroinflammat Res, 1st Hexie Rd, Ganzhou 341000, Peoples R China
来源：
CELLULAR AND MOLECULAR NEUROBIOLOGY | 2023年 / 43卷 / 06期
基金：
中国国家自然科学基金;
关键词：
Autophagy; Inflammation; Chronic cerebral ischaemia; WHITE-MATTER LESIONS; MICROGLIAL ACTIVATION; COGNITIVE IMPAIRMENT; REPERFUSION INJURY; RAT MODEL; HYPOPERFUSION; STROKE; ENVIRONMENT; DYSFUNCTION; MECHANISMS;
D O I：
10.1007/s10571-023-01336-6
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Chronic cerebral ischaemia (CCI) is a high-incidence cardiovascular and cerebrovascular disease that is very common in clinical practice. Although many pathogenic mechanisms have been explored, there is still great controversy among neuroscientists regarding the pathogenesis of CCI. Therefore, it is important to elucidate the mechanisms of CCI occurrence and progression for the prevention and treatment of ischaemic cerebrovascular disorders. Autophagy and inflammation play vital roles in CCI, but the relationship between these two processes in this disease remains unknown. Here, we review the progression and discuss the functions, actions and pathways of autophagy and inflammation in CCI, including a comprehensive view of the transition from acute disease to CCI through ischaemic repair mechanisms. This review may provide a reference for future research and treatment of CCI. [GRAPHICS]
引用
收藏
页码：2557 / 2566
页数：10
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