Application of seaweed polysaccharide in bone tissue regeneration

被引:5
|
作者
Jin, Ye [1 ,2 ]
Yu, Qixuan [1 ]
Li, Shuangyang [1 ]
Chen, Tianli [1 ]
Liu, Da [1 ]
机构
[1] Changchun Univ Chinese Med, Sch Pharm, Changchun, Jilin, Peoples R China
[2] Changchun Univ Chinese Med, Northeast Asia Res Inst Tradit Chinese Med, Changchun, Peoples R China
基金
中国国家自然科学基金; 中国博士后科学基金;
关键词
seaweed polysaccharide; polysaccharide sulfate; bone regeneration; novel formulation; regenerative medicine; ENDOTHELIAL GROWTH-FACTOR; SULFATED POLYSACCHARIDES; HYDROGEL SCAFFOLDS; DRUG-DELIVERY; ALGINIC ACID; CARRAGEENAN; FUCOIDAN; ALGAE; DIFFERENTIATION; DEGRADATION;
D O I
10.3389/fmars.2023.1202422
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Regeneration is a complex process influenced by many independent or combined factors, including inflammation, proliferation, and tissue remodeling. The ocean, the most extensive resource on Earth, is rich in Seaweed. With increasing research in recent years, researchers have discovered that seaweed polysaccharides have various pharmacological effects, including a particular efficacy in promoting bone tissue regeneration. However, the application of this material in the field of bone tissue engineering is very limited. However, there are few studies on the polysaccharide at home and abroad, and little is known about its potential application value in bone repair. In addition, the bioavailability of the seaweed polysaccharide is also low, and there are still many problems to be solved. For example, the ease of solubility of fucoidan in water is a key issue that restricts its practical application. In this review, we summarize the applications and mechanisms of seaweed polysaccharides in bone healing. We also propose to combine seaweed polysaccharides with novel technologies through different types of preparations, hydrogels, scaffolds, and 3D printing to improve their use in tissue healing and regeneration.
引用
收藏
页数:13
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