Stroke and Risk Factors in Antiphospholipid Syndrome

被引：2
|
作者：
Fan, Yangyi [1 ]
Xu, Yicheng [2 ]
Zhang, Sifan [3 ]
Song, Xiaodong [1 ,4 ]
Liu, Zunjing [1 ]
Tu, Wenjun [5 ]
Li, Chun [6 ]
机构：
[1] Peking Univ Peoples Hosp, Dept Neurol, Beijing 100044, Peoples R China
[2] Aerosp Ctr Hosp, Dept Neurol, Beijing 100049, Peoples R China
[3] Peking Univ Peoples Hosp, Beijing 100191, Peoples R China
[4] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing 400042, Peoples R China
[5] Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R China
[6] Peking Univ Peoples Hosp, Dept Rheumatol & Immunol, Beijing 100044, Peoples R China
来源：
JOURNAL OF PERSONALIZED MEDICINE | 2024年 / 14卷 / 01期
关键词：
stroke; antiphospholipid; risk factor; stroke recurrence; HYDROXYCHLOROQUINE; ANTIBODIES;
D O I：
10.3390/jpm14010024
中图分类号：
R19 [保健组织与事业（卫生事业管理）];
学科分类号：
摘要：
Stroke is considered one of the most common and life-threatening manifestations of antiphospholipid syndrome (APS), which leads to high mortality and permanent disability. This study investigated the prevalence and the potential risk factors of stroke in APS. We enrolled 361 APS patients retrospectively from 2009 to 2022 at Peking University People's Hospital. Stroke was found in 25.8% (93/361) of the participants. The multivariate logistic regression showed that hypertension, diabetes, livedo reticularis, and other central nervous system involvements were significant related factors for stroke. The use of hydroxychloroquine appeared to relate to a lower incidence of stroke. During a median follow-up of 3.0 years, 11.8% (11/93) of the individuals with a previous stroke developed stroke recurrence, and thrombocytopenia seemed to be a predictor of stroke recurrence.
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页数：11
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