HIV-Associated Microbial Translocation May Affect Cytokine Production of CD56bright NK Cells via Stimulation of Monocytes

被引：4

作者：

ToVinh, Michael ^{[1
,2
]}

Hoerr, Gregor ^{[1
,2
]}

Hoffmeister, Christoph ^{[1
,2
]}

Dobrikova, Kristiyana ^{[1
]}

Gotter, Christina ^{[1
,2
]}

Raabe, Jan ^{[1
]}

Kaiser, Kim M. ^{[1
]}

Ahmad, Sarah ^{[1
]}

Finnemann, Claudia ^{[1
]}

Matejec, Eyleen ^{[1
]}

Hack, Gudrun ^{[1
]}

Bischoff, Jenny ^{[1
]}

Rieke, Gereon J. ^{[1
]}

Schwarze-Zander, Carolynne ^{[1
,2
]}

Boesecke, Christoph ^{[1
,2
]}

van Bremen, Kathrin ^{[1
,2
]}

Wasmuth, Jan-Christian ^{[1
,2
]}

Eis-Huebinger, Anna M. ^{[3
]}

Streeck, Hendrik ^{[3
]}

Verhasselt, Hedda L. ^{[4
]}

Oldenburg, Johannes ^{[5
]}

Strassburg, Christian P. ^{[1
,2
]}

Rockstroh, Juergen K. ^{[1
,2
]}

Spengler, Ulrich ^{[1
,2
]}

Kraemer, Benjamin ^{[1
]}

Nattermann, Jacob ^{[1
,2
]}

机构：

[1] Univ Bonn, Univ Hosp Bonn, Med Fac, Dept Internal Med 1, Bonn, Germany

[2] German Ctr Infect Res, Themat Translat Units HIV, Cologne, Germany

[3] Univ Bonn, Univ Hosp, Inst Virol, Bonn, Germany

[4] Univ Duisburg Essen, Univ Hosp Essen, Inst Med Microbiol, Essen, Germany

[5] Univ Bonn, Univ Hosp Bonn, Med Fac, Inst Expt Hematol & Transfus Med, Bonn, Germany

来源：

JOURNAL OF INFECTIOUS DISEASES | 2023年 / 227卷 / 04期

关键词：

HIV; NK cell dysfunction; TGF-beta; immune activation; microbial translocation; monocytes; DISEASE PROGRESSION; PROLIFERATION; GROWTH;

D O I：

10.1093/infdis/jiac485

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The mechanisms involved in HIV-associated natural killer (NK) cell impairment are still incompletely understood. We observed HIV infection to be associated with increased plasma levels of IFABP, a marker for gut epithelial barrier dysfunction, and LBP, a marker for microbial translocation. Both IFABP and LBP plasma concentrations were inversely correlated with NK cell interferon-gamma production, suggesting microbial translocation to modulate NK cell functions. Accordingly, we found lipopolysaccharide to have an indirect inhibitory effect on NK cells via triggering monocytes' transforming growth factor-beta production. Taken together, our data suggest increased microbial translocation to be involved in HIV-associated NK cell dysfunction.

引用

页码：577 / 582

页数：6

共 49 条

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