An immunosuppressive ectoenzyme-expressing T cell population is associated with non-responsiveness to immune checkpoint blockade in metastatic melanoma patients

被引：0
|
作者：
Mitra, Ankita
Thompson, Brian
Woods, David M.
Weber, Jeffrey S.
机构：
来源：
CANCER RESEARCH | 2023年 / 83卷 / 07期
关键词：
D O I：
10.1158/1538-7445.AM2023-2283
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
2283
引用
收藏
页数：2
相关论文
共 50 条
  • [41] Is tebentafusp superior to combined immune checkpoint blockade and other systemic treatments in metastatic uveal melanoma? A comparative efficacy analysis with population adjustment
    Petzold, Anne
    Steeb, Theresa
    Wessely, Anja
    Koch, Elias A. T.
    Vera, Julio
    Berking, Carola
    Heppt, Markus, V
    CANCER TREATMENT REVIEWS, 2023, 115
  • [42] T cell repertoire sequencing reveals dynamics of response to dendritic cell vaccine plus dasatinib for checkpoint blockade resistant metastatic melanoma
    Quagliata, L.
    Looney, T.
    Storkus, W.
    Taylor, J.
    Topacio-Hall, D.
    Lowman, G.
    ANNALS OF ONCOLOGY, 2019, 30
  • [43] Phenotyping of cutaneous toxicities in patients with metastatic malignant melanoma treated with immune checkpoint blockade therapy at a UK tertiary care centre
    Ye, W.
    Kim, M.
    Fairfax, B. P.
    Coupe, N.
    Payne, M. J.
    Matin, R. N.
    CLINICAL AND EXPERIMENTAL DERMATOLOGY, 2022, 47 (02) : 448 - 450
  • [44] Physiological non-responsiveness and absence of activation induced cell death, of T cells rapidly re-expressing retrovirally-introduced TCRs after T cell activation
    van Loenen, Marleen
    Hagedoom, Renate
    van Egmond, Esther
    Willemze, Roelof
    Falkenburg, J. H. Frederik
    Heeraskerk, Mirjam
    BLOOD, 2007, 110 (11) : 681A - 682A
  • [45] Association between T cell repertoire diversification and both clinical response as well as toxicity following immune checkpoint blockade in metastatic cancer patients
    Oh, David Yoonsuk
    Cham, Jason
    Zhang, Li
    Fong, Grant
    Klinger, Mark
    Faham, Malek
    Fong, Lawrence
    JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (15)
  • [46] A comparison of myeloid-derived suppressor cell populations in patients with ulcerated vs non-ulcerated melanoma receiving immune checkpoint blockade
    Angell, Colin D.
    Sun, Steven H.
    Lapurga, Gabriella
    Benner, Brooke
    Quiroga, Dionisia
    Savardekar, Himanshu
    Divincenzo, Mallory J.
    Abood, David
    Stiff, Andrew
    Duggan, Megan
    Handley, Demond
    Nagle, Erin
    Howard, J. Harrison
    Shah, Hiral
    Kendra, Kari L.
    Carson III, William E.
    MELANOMA RESEARCH, 2025, 35 (02) : 102 - 108
  • [47] TGFß1 and BMP signals modulate CD8+ T cell functionality and responsiveness to immune checkpoint blockade therapy
    Saadey, Abbey
    Yousif, Amir
    Osborne, Nicole
    Shahinfar, Roya
    Castillo, Chelsea
    Laster, Brooke
    Rajeev, Meera
    Kumar, Shrea
    Webb, Amy
    Ghoneim, Hazem
    JOURNAL OF IMMUNOLOGY, 2023, 210 (01):
  • [48] Non-invasive biomarkers derived from the extracellular matrix associate with response to immune checkpoint blockade (anti-CTLA-4) in metastatic melanoma patients
    Jensen, Christina
    Madsen, Daniel Hargbol
    Hansen, Morten
    Schmidt, Henrik
    Svane, Inge Marie
    Karsdal, Morten Asser
    Willumsen, Nicholas
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2018, 6
  • [49] Racial Differences in Clinical Outcomes for Metastatic Renal Cell Carcinoma Patients Treated With Immune-Checkpoint Blockade
    Olsen, T. Anders
    Martini, Dylan J.
    Goyal, Subir
    Liu, Yuan
    Evans, Sean T.
    Magod, Benjamin
    Brown, Jacqueline T.
    Yantorni, Lauren
    Russler, Greta Anne
    Caulfield, Sarah
    Goldman, Jamie M.
    Harris, Wayne B.
    Kucuk, Omer
    Carthon, Bradley C.
    Master, Viraj A.
    Nazha, Bassel
    Bilen, Mehmet Asim
    FRONTIERS IN ONCOLOGY, 2021, 11
  • [50] Association of Circular RNA and Long Non-Coding RNA Dysregulation with the Clinical Response to Immune Checkpoint Blockade in Cutaneous Metastatic Melanoma
    Oliver, Javier
    Luis Onieva, Juan
    Garrido-Barros, Maria
    Berciano-Guerrero, Miguel-Angel
    Sanchez-Munoz, Alfonso
    Jose Lozano, Maria
    Farngren, Angela
    Alvarez, Martina
    Martinez-Galvez, Beatriz
    Perez-Ruiz, Elisabeth
    Alba, Emilio
    Cobo, Manuel
    Rueda-Dominguez, Antonio
    Barragan, Isabel
    BIOMEDICINES, 2022, 10 (10)
12345