Immunohistochemistry for PRAME in Dermatopathology

被引:12
|
作者
Lezcano, Cecilia [1 ]
Jungbluth, Achim A. [1 ]
Busam, Klaus J. [1 ]
机构
[1] Mem Sloan Kettering Canc Ctr, Dept Pathol & Lab Med, 1275 York Ave, New York, NY 10065 USA
基金
美国国家卫生研究院;
关键词
PRAME; immunohistochemistry; melanoma; nevus; dermatopathology; CANCER-TESTIS ANTIGENS; GENE-EXPRESSION SIGNATURE; IN-SITU HYBRIDIZATION; LYMPH-NODES; MALIGNANT-MELANOMA; MELANOCYTIC NEVI; CANCER/TESTIS ANTIGENS; EPIGENETIC REGULATION; BENIGN; DIAGNOSIS;
D O I
10.1097/DAD.0000000000002440
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Preferentially expressed antigen in melanoma (PRAME) is a tumor-associated antigen first identified in a melanoma patient and found to be expressed in most melanomas as well as in variable levels in other malignant neoplasms of epithelial, mesenchymal, or hematolymphoid lineage. Detection of PRAME expression in formalin-fixed paraffin-embedded tissue is possible by immunohistochemistry (IHC) with commercially available monoclonal antibodies. In situ and invasive melanoma frequently show a diffuse pattern of nuclear PRAME immunoreactivity which contrasts with the infrequent and typically nondiffuse staining seen in nevi. In many challenging melanocytic tumors, results of PRAME IHC and other ancillary tests correlate well, but not always: The tests are not interchangeable. Most metastatic melanomas are positive for PRAME, whereas nodal nevi are not. Numerous studies on PRAME IHC have become available in the past few years with results supporting the value of PRAME IHC as an ancillary tool in the evaluation of melanocytic lesions and providing insights into limitations in sensitivity and specificity as well as possible pitfalls that need to be kept in mind by practicing pathologists.
引用
收藏
页码:733 / 747
页数:15
相关论文
共 50 条
  • [31] The Diagnostic Value of 5-hMC and PRAME Immunohistochemistry in Melanocytic Lesions
    Yu, Yan Hong
    Wood, Kimberly
    Hosseini, Niloufar
    Dodington, David
    Ghazarian, Danny
    Kamil, Zaid Saeed
    LABORATORY INVESTIGATION, 2023, 103 (03) : S443 - S444
  • [32] Prognostic Value of BAP1 and PRAME Immunohistochemistry in Uveal Melanomas
    Han, Lucy
    Bloomer, Michele
    Pekmezci, Melike
    LABORATORY INVESTIGATION, 2020, 100 (SUPPL 1) : 1609 - 1610
  • [33] Correlation of FISH and PRAME Immunohistochemistry in Ambiguous Superficial Cutaneous Melanocytic Proliferations
    Harvey, Nathan T.
    Peverall, Joanne
    Acott, Nathan
    Ardakani, Nima Mesbah
    Leecy, Tamazin N.
    Iacobelli, Jean
    McCallum, Dugald
    Van Vliet, Chris
    Wood, Benjamin A.
    AMERICAN JOURNAL OF DERMATOPATHOLOGY, 2021, 43 (12) : 913 - 920
  • [34] PRAME Immunohistochemistry Expression as a Diagnostic Tool for Inflammatory Juvenile Conjunctival Nevus
    Steinbergs, Korina
    Charoenkijkajorn, Chaow
    Lin, Jonathan
    Zuraski, Connor
    LABORATORY INVESTIGATION, 2023, 103 (03) : S1481 - S1481
  • [35] Immunohistochemistry in Dermatopathology: A Review of the Most Commonly Used Antibodies (Part I)
    Fuertes, L.
    Santonja, C.
    Kutzner, H.
    Requena, L.
    ACTAS DERMO-SIFILIOGRAFICAS, 2013, 104 (02): : 99 - 127
  • [36] Immunohistochemistry in Dermatopathology: A Review of the Most Commonly Used Antibodies (Part II)
    Fuertes, L.
    Santonja, C.
    Kutzner, H.
    Requena, L.
    ACTAS DERMO-SIFILIOGRAFICAS, 2013, 104 (03): : 181 - 203
  • [37] Comparison of Immunohistochemistry for PRAME With Cytogenetic Test Results in the Evaluation of Challenging Melanocytic Tumors
    Lezcano, Cecilia
    Jungbluth, Achim A.
    Busam, Klaus J.
    AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2020, 44 (07) : 893 - 900
  • [38] PRAME immunohistochemistry for melanoma diagnosis: A STARD-compliant diagnostic accuracy study
    O'Connor, Michaela K.
    Dai, Hongyan
    Fraga, Garth R.
    JOURNAL OF CUTANEOUS PATHOLOGY, 2022, 49 (09) : 780 - 786
  • [39] PRAME immunohistochemistry is useful in the evaluation of conjunctival melanomas, nevi, and primary acquired melanosis
    LeBlanc, Robert E.
    Miller, Donald M.
    Zegans, Michael E.
    JOURNAL OF CUTANEOUS PATHOLOGY, 2021, 48 (12) : 1442 - 1448
  • [40] PRAME immunohistochemistry is useful in differentiating oral melanomas from nevi and melanotic macules
    Schmitt, Toby Alexander
    Lee, Jonathan Cassolato
    Martinka, Magdalena
    Ko, Kevin Yen Chen
    JOURNAL OF CUTANEOUS PATHOLOGY, 2023, 50 (03) : 275 - 278