Palladium-Catalyzed Regioselective Intermolecular Hydroalkoxylation of 1-Arylbutadienes

被引：7
|
作者：
Fernandes, Rodney A. [1 ]
Chandra, Naveen [1 ]
Gangani, Ashvin J. [1 ]
Khatun, Gulenur N. [1 ]
机构：
[1] Indian Inst Technol, Dept Chem, Mumbai 400076, Maharashtra, India
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 88卷 / 15期
关键词：
ENANTIOSELECTIVE ALLYLIC SUBSTITUTION; ASYMMETRIC-SYNTHESIS; ALKYLATION; 1,3-DIENES; ALCOHOLS; DIENES; ETHERIFICATION; ALLYLATION; HYDROAMINATION; AMINATION;
D O I：
10.1021/acs.joc.2c01252
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient method for the synthesis of (E)-(3-alkoxybut-1-enyl)benzenes by Pd-catalyzed regioselective intermolecular hydroalkoxylation of 1-arylbutadienes has been developed. This method can be executed in a simple operation with no dry reaction conditions required and having tolerance to a wide range of substrates. Chloromethyl methyl ether (MOMCl) as an additive was found to be essential for the success of the reaction.
引用
收藏
页码：10339 / 10354
页数：16
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