Efficacy of nano encapsulated herbal extracts in the treatment of induced wounds in animal models: a systematic review protocol

被引:0
|
作者
Namuga, Catherine [1 ,2 ]
Ocan, Moses [3 ,4 ]
Kinengyere, Alison A. [4 ,5 ]
Richard, Ssenono [4 ,6 ]
Namisango, Eve [4 ,7 ]
Muwonge, Haruna [8 ,9 ]
Kirabira, John Baptist [2 ]
Lawrence, Mugisha [10 ]
Obuku, Ekwaro A. [4 ]
机构
[1] Busitema Univ, Dept Polymer Text & Ind Engn, POB 236, Tororo, Uganda
[2] Makerere Univ, Coll Engn Design Art & Technol, Dept Mech Engn, POB 7062, Kampala, Uganda
[3] Makerere Univ, Coll Hlth Sci, Sch Biomed Sci, Dept Pharmacol, POB 7072, Kampala, Uganda
[4] Makerere Univ, Coll Hlth Sci, Afr Ctr Knowledge Translat & Systemat Reviews, Dept Med, POB 7072, Kampala, Uganda
[5] Makerere Univ, Albert Cook Lib, POB 7072, Kampala, Uganda
[6] Makerere Univ, Infect Dis Inst, POB 22418, Kampala, Uganda
[7] Makerere Univ, Sch Med, Dept Med, Clin Epidemiol Unit,Coll Hlth Sci, Kampala, Uganda
[8] Makerere Univ, Coll Hlth Sci, Dept Physiol, POB 7072, Kampala, Uganda
[9] Islamic Univ Uganda IUIU, Habib Med Sch, Dept Physiol, POB 7689, Kampala, Uganda
[10] Makerere Univ, Coll Vet Med, Anim Resources & Biosecur, POB 7072, Kampala, Uganda
关键词
Wounds; Wound healing; Herbal extracts; Nanoencapsulation; Nanocarriers; DRUG-DELIVERY SYSTEMS; NANOTECHNOLOGY; DRESSINGS; NANOMATERIALS; MEDICINES; QUALITY;
D O I
10.1186/s13643-023-02370-7
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
BackgroundWounds inflict pain and affect human health causing high expenditure on treatment and management. Herbal crude extracts are used in traditional medicine as a treatment for wounds and other illnesses. However, the progress in the use of plants has been deterred due to their poor solubility and poor bioavailability requiring administration at high doses. It has been established that nanoencapsulation of herbal products in nanocarriers (size 1 nm to 100 nm) such as nanofibers, nanoparticles, nanospheres, and nanoliposomes greatly improves their efficacy. Due to their small and large surface area, nanocarriers are more biologically active, improve bioavailability, protect the drug from deterioration, and release it to the targeted site in a sustainable manner.AimThe review aims to collate and appraise evidence on the efficacy of nano encapsulated herbal extracts in the treatment of induced wounds in animal models.MethodsThe review will be protocol-driven and conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis for Protocols (PRISMA-P) and protocol guidelines for systematic review and meta-analysis for animal intervention studies. The final review will be conducted and reported with reference to PRISMA 2020 statement. Studies will be searched in Pub Med, ProQuest, Web of Science, Medline Ovid, EMBASE, and Google Scholar. The PRISMA flow criteria will be followed in screening the articles for inclusion. Data extraction form will be designed in Excel spreadsheet 2013 and data extracted based on the primary and secondary outcomes. Risk of bias assessment will be done using SYRCLE's risk of bias tool for animal studies. Data analysis will be done using narrative and quantitative synthesis.Expected resultsWe hope to make meaningful comparisons between the effectiveness of the herb-loaded nanomaterials and other interventions (controls) in the selected studies, based on the primary and secondary outcome measures. We expect that these findings to inform clinical practice on whether preclinical studies show enough quality evidence on the efficacy and safety of herbal-loaded nanomaterials that can be translated into clinical trials and further research.Systemic review registrationPROSPERO 330330. The protocol was submitted on the 11th of May 2022.
引用
收藏
页数:8
相关论文
共 50 条
  • [21] A systematic review of the efficacy and safety of herbal medicines used in the treatment of obesity
    Shirin Hasani-Ranjbar
    Neda Nayebi
    Bagher Larijani
    Mohammad Abdollahi
    World Journal of Gastroenterology, 2009, 15 (25) : 3073 - 3085
  • [22] Efficacy and safety of regenerative cell therapy for pulmonary arterial hypertension in animal models: A preclinical systematic review protocol
    Suen C.M.
    Zhai A.
    Lalu M.M.
    Welsh C.
    Levac B.M.
    Fergusson D.
    McIntyre L.
    Stewart D.J.
    Systematic Reviews, 5 (1)
  • [23] Efficacy and safety of damage control in experimental animal models of injury: Protocol for a systematic review and meta-analysis
    Cosic N.
    Roberts D.J.
    Stelfox H.T.
    Systematic Reviews, 3 (1)
  • [24] Sex-based analysis of treatment responses in animal models of sepsis: a preclinical systematic review protocol
    Zhang, MengQi
    Fergusson, Dean
    Sharma, Rahul
    Khoo, Ciel L.
    Mendelson, Asher C.
    McDonald, Braedon
    Macala, Kimberly M.
    Sharma, Neha T.
    Gill, Sean T.
    Fiest, Kirsten
    Lehmann, Christian
    Shorr, Risa
    Jahandideh, Forough
    Bourque, Stephane
    Liaw, Patricia
    Fox-Robichaud, Alison
    Lalu, Manoj
    SYSTEMATIC REVIEWS, 2023, 12 (01)
  • [25] Sex-based analysis of treatment responses in animal models of sepsis: a preclinical systematic review protocol
    MengQi Zhang
    Dean A. Fergusson
    Rahul Sharma
    Ciel Khoo
    Asher A. Mendelson
    Braedon McDonald
    Kimberly F. Macala
    Neha Sharma
    Sean E. Gill
    Kirsten M. Fiest
    Christian Lehmann
    Risa Shorr
    Forough Jahandideh
    Stephane L. Bourque
    Patricia C. Liaw
    Alison Fox-Robichaud
    Manoj M. Lalu
    Systematic Reviews, 12
  • [26] Adjuvant therapy of Chinese herbal medicine for the treatment of adenomyosis A protocol for systematic review
    Huang, Li
    Ji, Xiaoli
    Wang, Xia
    Wu, Yang
    Luo, Mei
    Hao, Xiaotong
    Wei, Shaobin
    MEDICINE, 2020, 99 (25) : E20560
  • [27] Efficacy and safety of traditional Chinese herbal medicine in the treatment of threatened abortion A protocol for systematic review and meta-analysis
    Zeng, Pengfei
    Zhou, Hang
    Guo, Pei
    Xia, Wanting
    Huang, Jinzhu
    Zeng, Qian
    MEDICINE, 2021, 100 (05) : E23288
  • [28] Efficacy of acupuncture combined with Chinese herbal medicine for the treatment of chronic nephritis A protocol for systematic review and meta-analysis
    Zheng, Xue
    Zhang, Shoulin
    Wang, Zhilei
    Zou, Di
    MEDICINE, 2021, 100 (44)
  • [29] Most appropriate animal models to study the efficacy of statins: a systematic review
    Pecoraro, Valentina
    Moja, Lorenzo
    Dall'Olmo, Luigi
    Cappellini, Glauco
    Garattini, Silvio
    EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2014, 44 (09) : 848 - 871
  • [30] The efficacy of platelet-derived extracellular vesicles in the treatment of diabetic wounds: a systematic review and meta-analysis of animal studies
    Cai, Zhi
    Wang, Yuhan
    Hu, Shan
    Yuan, Qiong
    Liu, Jusong
    Luo, Chengcen
    Jiang, Ling
    Huang, Yuanshuai
    ARCHIVES OF DERMATOLOGICAL RESEARCH, 2025, 317 (01)