The effect of zinc doping on the cytocompatibility and antibacterial efficacy of hydroxyapatite nanoparticles for treatment of bone infection

被引：3
|
作者：
Cuypers, L. A. B. [1 ]
Bertsch, P. [1 ]
Wang, R. [1 ]
Harhangi, H. R. [2 ]
Joziasse, L. S. [1 ]
Walboomers, X. F. [1 ]
van Niftrik, L. [2 ]
Yang, F. [1 ]
Leeuwenburgh, S. C. G. [1 ]
机构：
[1] Radboud Univ Nijmegen, Med Ctr, Dept Dent Regenerat Biomat, Philips van Leydenlaan 25, NL-6525 EX Nijmegen, Netherlands
[2] Radboud Univ Nijmegen, Fac Sci, Dept Microbiol, Heyendaalseweg 135, NL-6525 AJ Nijmegen, Netherlands
来源：
OPEN CERAMICS | 2023年 / 16卷
基金：
荷兰研究理事会;
关键词：
Staphylococcus aureus; Hydroxyapatite; Metal ions; Zinc; Cytocompatibility; Antibacterial properties; NANO-HYDROXYAPATITE; DOPED HYDROXYAPATITE; DELIVERY; IONS; ANTIBIOTICS; EFFICIENT; TOXICITY; SYSTEM; COPPER; SHAPE;
D O I：
10.1016/j.oceram.2023.100488
中图分类号：
TQ174 [陶瓷工业]; TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
In the face of antibiotic resistance, new antibacterial methods are urgently needed for bone infections. Local delivery of therapeutic metal ions via osteogenic nanoparticles (NPs) is a viable alternative, but high concentrations risk toxicity to mammalian cells. In this study first four ions (Mg2+, Sr2+, Cu2+, Zn2+) were assessed for cytocompatibility and antibacterial properties. Only zinc ions showed antibacterial effects at non-toxic levels. Subsequently, zinc-doped hydroxyapatite nanoparticles (ZnHA NPs) were synthesized with varying zinc content (0-20 mol%). ZnHA NPs were characterized on size, morphology, composition, and antibacterial activity, with 15 mol% ZnHA NPs exhibiting the optimal balance between cytocompatibility and antibacterial efficacy. These NPs show promise as deliverable biomaterials for bone infection treatment.
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页数：10
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