Synthesis of Fluoroalkyl- and Fluoroaryl-Substituted Hexahydropyrimidines

被引：0

作者：

Gibadullina, N. N. ^{[1
]}

Dokichev, V. A. ^{[1
]}

机构：

[1] Russian Acad Sci, Ufa Inst Chem, Ufa Fed Res Ctr, Ufa 450054, Russia

来源：

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 59卷 / 04期

关键词：

hexahydropyrimidine; fluorinated; 1; 3-dicarbonyl compounds; Biginelli reaction; Mannich reaction; SOLVENT-FREE SYNTHESIS; ONE-POT SYNTHESIS; BIGINELLI REACTION; 1,3-DICARBONYL COMPOUNDS; BIOLOGICAL EVALUATION; DERIVATIVES; DIHYDROPYRIMIDIN-2(1H)-ONES; EFFICIENT; DESIGN; SILICA;

D O I：

10.1134/S1070428023040012

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Data on the synthesis of fluoroalkyl- and fluoroaryl-substituted hexahydropyrimidine derivatives since their first publication have been systemized. One-pot multicomponent synthetic methods, including catalytic ones, have been mainly considered. The effects of the nature of catalyst and initial reactants and reaction conditions on the product yield and composition have been discussed. Biological activity of some hexahydropyrimidine derivatives has been noted.

引用

页码：553 / 566

页数：14

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